Howell JC, Watts KD, Parker MW, Wu J, Kollhoff A, Wingo TS, Dorbin CD, Qiu D, Hu WT. Race modifies the relationship between cognition and Alzheimer's disease cerebrospinal fluid biomarkers. Alzheimers Res Ther. 2017 Nov 2;9(1):88. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ40
(CSF)		 AD
(10)		 9.49 ± 3.61
ng/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
Aβ40
(CSF)		 AD
(15)		 7.91 ± 2.54
ng/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
Aβ40
(CSF)		 CTRL-
CNC
(23)		 7.21 ± 1.96
ng/mL §		 ELISA;
Innotest;
Fujirebio
Aβ40
(CSF)		 CTRL-
CNC
(28)		 10.03 ± 3.65
ng/mL §		 ELISA;
Innotest;
Fujirebio
Aβ42
(CSF)		 AD
(10)		 158 ± 105
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
Aβ42
(CSF)		 AD
(15)		 96 ± 61
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
Aβ42
(CSF)		 CTRL-
CNC
(23)		 273 ± 110
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio
Aβ42
(CSF)		 CTRL-
CNC
(28)		 250 ± 131
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio
NFL
(CSF)		 AD
(10)		 1570.8 ± 865.8
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 McKhann et al., 1984; Dubois et al., 2007
NFL
(CSF)		 AD
(15)		 1176.27 ± 599.93
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 McKhann et al., 1984; Dubois et al., 2007
NFL
(CSF)		 CTRL-
CNC
(23)		 673.83 ± 459.31
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(CSF)		 CTRL-
CNC
(28)		 1026.93 ± 570.44
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB
tau-p181
(CSF)		 AD
(10)		 25.3 ± 10.3
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
tau-p181
(CSF)		 AD
(15)		 34.2 ± 14.9
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
tau-p181
(CSF)		 CTRL-
CNC
(23)		 13.8 ± 5.1
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio
tau-p181
(CSF)		 CTRL-
CNC
(28)		 22.5 ± 9.8
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio
tau-total
(CSF)		 AD
(10)		 72.8 ± 27.5
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
tau-total
(CSF)		 AD
(15)		 103.8 ± 72.9
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 1984; Dubois et al., 2007
tau-total
(CSF)		 CTRL-
CNC
(23)		 36.3 ± 12
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio
tau-total
(CSF)		 CTRL-
CNC
(28)		 58.6 ± 29
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio
α-synuclein
(CSF)		 AD
(10)		 483.83 ± 339.07
pg/mL §		 ELISA;
Novex;
Thermo Fisher Scientific		 McKhann et al., 1984; Dubois et al., 2007
α-synuclein
(CSF)		 AD
(15)		 443.19 ± 279.9
pg/mL §		 ELISA;
Novex;
Thermo Fisher Scientific		 McKhann et al., 1984; Dubois et al., 2007
α-synuclein
(CSF)		 CTRL-
CNC
(23)		 295.99 ± 295.33
pg/mL §		 ELISA;
Novex;
Thermo Fisher Scientific
α-synuclein
(CSF)		 CTRL-
CNC
(28)		 458.38 ± 451.08
pg/mL §		 ELISA;
Novex;
Thermo Fisher Scientific

§ Data supplied to Alzforum by author

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AlzBiomarker

  1. AD vs CTRL : Aβ40 (CSF)
  2. CTRL vs AD : Aβ40 (CSF)
  3. AD vs CTRL : Aβ42 (CSF)
  4. CTRL vs AD : Aβ42 (CSF)
  5. AD vs CTRL : NFL (CSF)
  6. CTRL vs AD : NFL (CSF)
  7. AD vs CTRL : tau-p181 (CSF)
  8. CTRL vs AD : tau-p181 (CSF)
  9. AD vs CTRL : tau-total (CSF)
  10. CTRL vs AD : tau-total (CSF)
  11. AD vs CTRL : α-synuclein (CSF)
  12. CTRL vs AD : α-synuclein (CSF)