Morenas-Rodríguez E, Cervera-Carles L, Vilaplana E, Alcolea D, Carmona-Iragui M, Dols-Icardo O, Ribosa-Nogué R, Muñoz-Llahuna L, Sala I, Belén Sánchez-Saudinós M, Blesa R, Clarimón J, Fortea J, Lleó A. Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias. J Alzheimers Dis. 2015;50(2):539-46. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(73)		 352 ± 115.9
pg/mL		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 2011; Albert et al., 2011
Aβ42
(CSF)		 CTRL-
CNC
(74)		 811.9 ± 163.9
pg/mL		 ELISA;
Innotest;
Fujirebio
Aβ42
(CSF)		 FTD
(32)		 604.5 ± 285.1
pg/mL		 ELISA;
Innotest;
Fujirebio		 Rascovsky et al., 2011
YKL-40
(CSF)		 AD
(73)		 267.5 ± 52.8
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 McKhann et al., 2011; Albert et al., 2011
YKL-40
(CSF)		 CTRL-
CNC
(74)		 195.1 ± 44.6
ng/mL		 ELISA;
Other/Not Specified;
Quidel Corporation
YKL-40
(CSF)		 FTD
(32)		 257.7 ± 62.3
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 Rascovsky et al., 2011
tau-p181
(CSF)		 AD
(73)		 91.3 ± 33.4
pg/mL		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 2011; Albert et al., 2011
tau-p181
(CSF)		 CTRL-
CNC
(74)		 40.4 ± 11.5
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-p181
(CSF)		 FTD
(32)		 46.3 ± 24.9
pg/mL		 ELISA;
Innotest;
Fujirebio		 Rascovsky et al., 2011
tau-total
(CSF)		 AD
(73)		 740 ± 401.3
pg/mL		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 McKhann et al., 2011; Albert et al., 2011
tau-total
(CSF)		 CTRL-
CNC
(74)		 202.1 ± 68.2
pg/mL		 ELISA;
Innotest hTAU-Ag;
Fujirebio
tau-total
(CSF)		 FTD
(32)		 313.4 ± 210.5
pg/mL		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 Rascovsky et al., 2011

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News

  1. Progranulin: A Mark of Worsening Alzheimer’s?

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. FTD vs AD : Aβ42 (CSF)
  4. AD vs CTRL : YKL-40 (CSF)
  5. CTRL vs AD : YKL-40 (CSF)
  6. FTD vs AD : YKL-40 (CSF)
  7. AD vs CTRL : tau-p181 (CSF)
  8. CTRL vs AD : tau-p181 (CSF)
  9. FTD vs AD : tau-p181 (CSF)
  10. AD vs CTRL : tau-total (CSF)
  11. CTRL vs AD : tau-total (CSF)
  12. FTD vs AD : tau-total (CSF)