Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ, Airey DC, Knopman DS, Roberts RO, Machulda MM, Jack CR Jr, Petersen RC, Dage JL. Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography. Alzheimers Dement. 2018 Aug;14(8):989-997. Epub 2018 Apr 5 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
tau-p181
(Plasma)		 AD
(40)		 11.6 ± 4.1
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 McKhann et al., 2011
tau-p181
(Plasma)		 CTRL-
CNC
(172)		 6.4 ± 6.4
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
tau-total
(Plasma)		 AD
(40)		 7.2 ± 2.8
pg/mL		 SIMOA;
hTau kit (101444);
Quanterix		 McKhann et al., 2011
tau-total
(Plasma)		 CTRL-
CNC
(172)		 5.9 ± 1.9
pg/mL		 SIMOA;
hTau kit (101444);
Quanterix

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AlzBiomarker

  1. AD vs CTRL : tau-p181 (Plasma and Serum)
  2. CTRL vs AD : tau-p181 (Plasma and Serum)
  3. AD vs CTRL : tau-total (Plasma and Serum)
  4. CTRL vs AD : tau-total (Plasma and Serum)