Kovacs GG, Andreasson U, Liman V, Regelsberger G, Lutz MI, Danics K, Keller E, Zetterberg H, Blennow K. Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort. Eur J Neurol. 2017 Nov;24(11):1326-e77. Epub 2017 Aug 16 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
NFL
(CSF)		 AD
(14)		 6137.14 ± 1969.47†
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(CSF)		 CTRL-
CNC
(18)		 1615.89 ± 296.505†
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(CSF)		 gCJD-
E200K
(16)		 13189.8 ± 1608.64†
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(CSF)		 sCJD
(46)		 11368.3 ± 1387.39†
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(Plasma)		 AD
(21)		 325.871 ± 167.82†
pg/mL		 SIMOA;
Other/Not Specified;
Uman Diagnostics AB/Quanterix
NFL
(Plasma)		 CTRL-
CNC
(18)		 26.617 ± 3.0674†
pg/mL		 SIMOA;
Other/Not Specified;
Uman Diagnostics AB/Quanterix
tau-total
(CSF)		 AD
(14)		 1406.57 ± 612.235†
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-total
(CSF)		 CTRL-
CNC
(18)		 300.39 ± 21.093†
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-total
(CSF)		 gCJD-
E200K
(16)		 8010.63 ± 2446.82†
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-total
(CSF)		 sCJD
(45)		 10918.9 ± 1797.73†
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-total
(Plasma)		 AD
(21)		 7.5043 ± 3.01959†
pg/mL		 SIMOA;
Human Total Tau;
Quanterix
tau-total
(Plasma)		 CTRL-
CNC
(18)		 1.6862 ± 0.17034†
pg/mL		 SIMOA;
Human Total Tau;
Quanterix
tau-total
(Plasma)		 sCJD
(65)		 17.1712 ± 2.10238†
pg/mL		 SIMOA;
Human Total Tau;
Quanterix

† Mean ± SEM

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AlzBiomarker

  1. AD vs CTRL : NFL (CSF)
  2. AD vs CTRL : NFL (Plasma and Serum)
  3. CTRL vs AD : NFL (CSF)
  4. CTRL vs AD : NFL (Plasma and Serum)
  5. gCJD vs AD : NFL (CSF)
  6. sCJD vs AD : NFL (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. AD vs CTRL : tau-total (Plasma and Serum)
  9. CTRL vs AD : tau-total (CSF)
  10. CTRL vs AD : tau-total (Plasma and Serum)
  11. gCJD vs AD : tau-total (CSF)
  12. sCJD vs AD : tau-total (CSF)
  13. sCJD vs AD : tau-total (Plasma and Serum)