AlzBiomarker
Creutzfeldt-Jakob Disease (Sporadic) vs Alzheimer's Disease: tau-total (Plasma and Serum)
During the past decade, the development of highly sensitive assays—like SIMOA and immunomagnetic reduction—has permitted the quantification of biomolecules in blood. Our meta-analysis of more than 30 comparisons showd that the level of tau in the blood of Alzheimer's patients is about 40 percent greater than that of control subjects. Tau is further elevated in people with Creutzfeldt-Jakob disease: Meta-analysis of two studies showed a greater than five-fold increase in plasma tau in sCJD compared with AD (effect size = 5.599), although the p value (0.04) was only marginally signficant.
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