Choi C, Jeong JH, Jang JS, Choi K, Lee J, Kwon J, Choi KG, Lee JS, Kang SW. Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology. J Clin Neurol. 2008 Jun;4(2):84-8. Epub 2008 Jun 20 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : MCP-1 (CSF)
- AD vs CTRL : MCP-1 (Plasma and Serum)
- CTRL vs AD : MCP-1 (CSF)
- CTRL vs AD : MCP-1 (Plasma and Serum)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (11) |
0.3 ± 0.1 ng/mL |
xMAP; Other/Not Specified; Biosource |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (13) |
0.4 ± 0.2 ng/mL |
xMAP; Other/Not Specified; Biosource |
|
| MCP-1 (CSF) |
AD (11) |
2 ± 1.1 ng/mL |
xMAP; Beadlyte Human Multicytokine Beadmaster kit; Upstate |
McKhann et al., 1984 |
| MCP-1 (CSF) |
CTRL- CNC (13) |
1.8 ± 0.6 ng/mL |
xMAP; Beadlyte Human Multicytokine Beadmaster kit; Upstate |
|
| MCP-1 (Serum) |
AD (11) |
22.3 ± 31.9 ng/mL |
xMAP; Beadlyte Human Multicytokine Beadmaster kit; Upstate |
McKhann et al., 1984 |
| MCP-1 (Serum) |
CTRL- CNC (13) |
11.4 ± 7.7 ng/mL |
xMAP; Beadlyte Human Multicytokine Beadmaster kit; Upstate |
|
| tau-total (CSF) |
AD (11) |
1.2 ± 0.9 ng/mL |
xMAP; Other/Not Specified; Biosource |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (13) |
0.9 ± 0.5 ng/mL |
xMAP; Other/Not Specified; Biosource |
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