Paper
- Alzforum Recommends
Bolmont T, Clavaguera F, Meyer-Luehmann M, Herzig MC, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. Am J Pathol. 2007 Dec;171(6):2012-20. PubMed.
Recommends
Please login to recommend the paper.
Comments
Inserm
Based upon neuropathological and biochemical observations of the human brain, a relevant model of Alzheimer pathology should present a synergy between tauopathy and amyloidosis. The model presented here sounds good.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology. 2002 Aug 13;59(3):398-407. PubMed.
Make a Comment
To make a comment you must login or register.