Jiao SS, Bu XL, Liu YH, Wang QH, Liu CH, Yao XQ, Zhou XF, Wang YJ. Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker. Transl Psychiatry. 2015 Oct 6;5:e650. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ40
(CSF)		 AD
(25)		 367.3 ± 98.4
pg/mL		 ELISA;
SIG-38590;
Covance		 McKhann et al., 1984; 1993
Aβ40
(CSF)		 CTRL-
CNC
(26)		 392.9 ± 65.1
pg/mL		 ELISA;
SIG-38590;
Covance
Aβ40
(Serum)		 AD
(156)		 86.2 ± 55.5
pg/mL		 ELISA;
SIG-38590;
Covance		 McKhann et al., 1984; 1993
Aβ40
(Serum)		 CTRL-
CNC
(129)		 60.2 ± 34.7
pg/mL		 ELISA;
SIG-38590;
Covance
Aβ42
(CSF)		 AD
(25)		 243.4 ± 99.9
pg/mL		 ELISA;
SIG-38593;
Covance		 McKhann et al., 1984; 1993
Aβ42
(CSF)		 CTRL-
CNC
(26)		 425.7 ± 140.5
pg/mL		 ELISA;
SIG-38593;
Covance
Aβ42
(Serum)		 AD
(156)		 68.4 ± 61.9
pg/mL		 ELISA;
SIG-38593;
Covance		 McKhann et al., 1984; 1993
Aβ42
(Serum)		 CTRL-
CNC
(129)		 49.3 ± 27.7
pg/mL		 ELISA;
SIG-38593;
Covance
tau-p181
(CSF)		 AD
(25)		 127.5 ± 53.5
pg/mL		 ELISA;
KUO0631;
Invitrogen		 McKhann et al., 1984; 1993
tau-p181
(CSF)		 CTRL-
CNC
(26)		 55.4 ± 29.2
pg/mL		 ELISA;
KUO0631;
Invitrogen
tau-p181
(Serum)		 AD
(156)		 150.8 ± 57.7
pg/mL		 ELISA;
KUO0631;
Invitrogen		 McKhann et al., 1984; 1993
tau-p181
(Serum)		 CTRL-
CNC
(129)		 107.1 ± 57.8
pg/mL		 ELISA;
KUO0631;
Invitrogen
tau-total
(CSF)		 AD
(25)		 466.8 ± 231.2
pg/mL		 ELISA;
KUB0041;
Invitrogen		 McKhann et al., 1984; 1993
tau-total
(CSF)		 CTRL-
CNC
(26)		 325.5 ± 104.7
pg/mL		 ELISA;
KUB0041;
Invitrogen
tau-total
(Serum)		 AD
(156)		 227.1 ± 102.2
pg/mL		 ELISA;
KUB0041;
Invitrogen		 McKhann et al., 1984; 1993
tau-total
(Serum)		 CTRL-
CNC
(129)		 181 ± 103.2
pg/mL		 ELISA;
KUB0041;
Invitrogen

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AlzBiomarker

  1. AD vs CTRL : Aβ40 (CSF)
  2. AD vs CTRL : Aβ40 (Plasma and Serum)
  3. CTRL vs AD : Aβ40 (CSF)
  4. CTRL vs AD : Aβ40 (Plasma and Serum)
  5. AD vs CTRL : Aβ42 (CSF)
  6. AD vs CTRL : Aβ42 (Plasma and Serum)
  7. CTRL vs AD : Aβ42 (CSF)
  8. CTRL vs AD : Aβ42 (Plasma and Serum)
  9. AD vs CTRL : tau-p181 (CSF)
  10. AD vs CTRL : tau-p181 (Plasma and Serum)
  11. CTRL vs AD : tau-p181 (CSF)
  12. CTRL vs AD : tau-p181 (Plasma and Serum)
  13. AD vs CTRL : tau-total (CSF)
  14. AD vs CTRL : tau-total (Plasma and Serum)
  15. CTRL vs AD : tau-total (CSF)
  16. CTRL vs AD : tau-total (Plasma and Serum)