Engelborghs S, De Vreese K, Van de Casteele T, Vanderstichele H, Van Everbroeck B, Cras P, Martin JJ, Vanmechelen E, De Deyn PP. Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia. Neurobiol Aging. 2008 Aug;29(8):1143-59. Epub 2007 Apr 10 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (51) |
353 ± 140 pg/mL |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (CSF) |
CTRL- Other Controls (97) |
699 ± 155 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-p181 (CSF) |
AD (51) |
68.1 ± 26 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-p181 (CSF) |
CTRL- Other Controls (97) |
40.9 ± 15.5 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (51) |
560 ± 284 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
CTRL- Other Controls (97) |
231 ± 149 pg/mL |
ELISA; Innotest; Innogenetics |
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