Paper
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Fagan AM, Head D, Shah AR, Marcus D, Mintun M, Morris JC, Holtzman DM. Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly. Ann Neurol. 2009 Feb;65(2):176-83. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ40 (CSF)
- AD vs CTRL : Aβ40 (Plasma and Serum)
- CTRL vs AD : Aβ40 (CSF)
- CTRL vs AD : Aβ40 (Plasma and Serum)
- AD vs CTRL : Aβ42 (CSF)
- AD vs CTRL : Aβ42 (Plasma and Serum)
- CTRL vs AD : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (Plasma and Serum)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ40 (CSF) |
AD (29) |
10613 ± 3787 pg/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| Aβ40 (CSF) |
CTRL- CNC (69) |
10524 ± 3837 pg/mL |
ELISA; Other/Not Specified; In-house |
|
| Aβ40 (Plasma) |
AD (29) |
194 ± 81 pg/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| Aβ40 (Plasma) |
CTRL- CNC (69) |
220 ± 113 pg/mL |
ELISA; Other/Not Specified; In-house |
|
| Aβ42 (CSF) |
AD (29) |
472 ± 186 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (69) |
572 ± 208 pg/mL |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (Plasma) |
AD (29) |
40 ± 44 pg/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| Aβ42 (Plasma) |
CTRL- CNC (69) |
64 ± 120 pg/mL |
ELISA; Other/Not Specified; In-house |
|
| tau-p181 (CSF) |
AD (29) |
82 ± 46 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
CTRL- CNC (69) |
61 ± 27 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (29) |
534 ± 304 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (69) |
334 ± 180 pg/mL |
ELISA; Innotest; Innogenetics |
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AlzBiomarker
- AD vs CTRL : Aβ40 (CSF)
- AD vs CTRL : Aβ40 (Plasma and Serum)
- CTRL vs AD : Aβ40 (CSF)
- CTRL vs AD : Aβ40 (Plasma and Serum)
- AD vs CTRL : Aβ42 (CSF)
- AD vs CTRL : Aβ42 (Plasma and Serum)
- CTRL vs AD : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (Plasma and Serum)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
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