Alcolea D, Vilaplana E, Suárez-Calvet M, Illán-Gala I, Blesa R, Clarimón J, Lladó A, Sánchez-Valle R, Molinuevo JL, García-Ribas G, Compta Y, Martí MJ, Piñol-Ripoll G, Amer-Ferrer G, Noguera A, García-Martín A, Fortea J, Lleó A. CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration. Neurology. 2017 Jul 11;89(2):178-188. Epub 2017 Jun 7 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(72)		 346.3 ± 105.2
pg/mL §		 ELISA;
;
Fujirebio		 McKhann et al., 2011
Aβ42
(CSF)		 CBS
(20)		 480.1 ± 165.3
pg/mL §		 ELISA;
;
Fujirebio
Aβ42
(CSF)		 CTRL
(56)		 780.4 ± 145.7
pg/mL §		 ELISA;
;
Fujirebio
Aβ42
(CSF)		 FTD-
FTLD-TDP43
(15)		 594.2 ± 236.3
pg/mL §		 ELISA;
;
Fujirebio
Aβ42
(CSF)		 FTD-
bvFTD
(68)		 653 ± 270.7
pg/mL §		 ELISA;
;
Fujirebio		 Rascovsky et al., 2011
Aβ42
(CSF)		 FTD-
nfvPPA
(23)		 637.7 ± 168.5
pg/mL §		 ELISA;
;
Fujirebio		 Gorno-Tempini et al., 2011
Aβ42
(CSF)		 FTD-
svPPA
(19)		 764.5 ± 247.6
pg/mL §		 ELISA;
;
Fujirebio		 Gorno-Tempini et al., 2011
Aβ42
(CSF)		 PSP
(28)		 452.2 ± 198.6
pg/mL §		 ELISA;
;
Fujirebio		 Litvan et al., 1996
NFL
(CSF)		 AD
(55)		 1051.8 ± 395.4
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 McKhann et al., 2011
NFL
(CSF)		 CBS
(19)		 2264.3 ± 1216.5
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(CSF)		 CTRL
(56)		 447.6 ± 207.4
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB
NFL
(CSF)		 FTD-
bvFTD
(54)		 2174.4 ± 2394.9
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 Rascovsky et al., 2011
NFL
(CSF)		 FTD-
nfvPPA
(10)		 2042.4 ± 1617.3
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 Gorno-Tempini et al., 2011
NFL
(CSF)		 FTD-
svPPA
(11)		 2394.4 ± 1388.1
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 Gorno-Tempini et al., 2011
NFL
(CSF)		 PSP
(28)		 1469.8 ± 656.9
pg/mL §		 ELISA;
NF-light;
UmanDiagnostics AB		 Litvan et al., 1996
YKL-40
(CSF)		 AD
(70)		 280.3 ± 47.6
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation		 McKhann et al., 2011
YKL-40
(CSF)		 CBS
(21)		 280.6 ± 60.4
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation
YKL-40
(CSF)		 CTRL
(56)		 195.9 ± 43
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation
YKL-40
(CSF)		 FTD-
FTLD-TDP43
(14)		 266.2 ± 63.8
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation
YKL-40
(CSF)		 FTD-
bvFTD
(63)		 253.6 ± 69.1
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation		 Rascovsky et al., 2011
YKL-40
(CSF)		 FTD-
nfvPPA
(23)		 287.5 ± 59
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation		 Gorno-Tempini et al., 2011
YKL-40
(CSF)		 FTD-
svPPA
(15)		 287.1 ± 49.9
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation		 Gorno-Tempini et al., 2011
YKL-40
(CSF)		 PSP
(21)		 253.3 ± 61.3
ng/mL §		 ELISA;
MicroVue;
Quidel Corporation		 Litvan et al., 1996
sAPPβ
(CSF)		 AD
(72)		 1015.5 ± 346.7
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL		 McKhann et al., 2011
sAPPβ
(CSF)		 CBS
(21)		 556.4 ± 226.9
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL
sAPPβ
(CSF)		 CTRL
(56)		 972.8 ± 383.8
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL
sAPPβ
(CSF)		 FTD-
FTLD-TDP43
(15)		 562.1 ± 196.5
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL
sAPPβ
(CSF)		 FTD-
bvFTD
(68)		 546.6 ± 243.3
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL		 Rascovsky et al., 2011
sAPPβ
(CSF)		 FTD-
nfvPPA
(23)		 639.6 ± 296.5
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL		 Gorno-Tempini et al., 2011
sAPPβ
(CSF)		 FTD-
svPPA
(19)		 596.9 ± 233.8
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL		 Gorno-Tempini et al., 2011
sAPPβ
(CSF)		 PSP
(28)		 543.7 ± 246
ng/mL §		 ELISA;
human sAPPβ-w, highly sensitive;
IBL		 Litvan et al., 1996
tau-p181
(CSF)		 AD
(72)		 106 ± 34.5
pg/mL §		 ELISA;
;
Fujirebio		 McKhann et al., 2011
tau-p181
(CSF)		 CBS
(21)		 43.4 ± 13.3
pg/mL §		 ELISA;
;
Fujirebio
tau-p181
(CSF)		 CTRL
(56)		 39.2 ± 10.7
pg/mL §		 ELISA;
;
Fujirebio
tau-p181
(CSF)		 FTD-
FTLD-TDP43
(15)		 37.3 ± 8.9
pg/mL §		 ELISA;
;
Fujirebio
tau-p181
(CSF)		 FTD-
bvFTD
(68)		 43.5 ± 20.8
pg/mL §		 ELISA;
;
Fujirebio		 Rascovsky et al., 2011
tau-p181
(CSF)		 FTD-
nfvPPA
(23)		 60.8 ± 29.7
pg/mL §		 ELISA;
;
Fujirebio		 Gorno-Tempini et al., 2011
tau-p181
(CSF)		 FTD-
svPPA
(19)		 47.8 ± 18.2
pg/mL §		 ELISA;
;
Fujirebio		 Gorno-Tempini et al., 2011
tau-p181
(CSF)		 PSP
(28)		 34.9 ± 23.9
pg/mL §		 ELISA;
;
Fujirebio		 Litvan et al., 1996
tau-total
(CSF)		 AD
(72)		 844.9 ± 370.5
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 McKhann et al., 2011
tau-total
(CSF)		 CBS
(21)		 279.5 ± 108
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio
tau-total
(CSF)		 CTRL
(56)		 194 ± 64.1
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio
tau-total
(CSF)		 FTD-
FTLD-TDP43
(15)		 269 ± 100.2
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio
tau-total
(CSF)		 FTD-
bvFTD
(68)		 273.8 ± 151.5
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 Rascovsky et al., 2011
tau-total
(CSF)		 FTD-
nfvPPA
(23)		 376.2 ± 222.9
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 Gorno-Tempini et al., 2011
tau-total
(CSF)		 FTD-
svPPA
(19)		 315.4 ± 158.3
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 Gorno-Tempini et al., 2011
tau-total
(CSF)		 PSP
(28)		 214.9 ± 131.6
pg/mL §		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 Litvan et al., 1996

§ Data supplied to Alzforum by author

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CBS vs AD : Aβ42 (CSF)
  3. CTRL vs AD : Aβ42 (CSF)
  4. FTD vs AD : Aβ42 (CSF)
  5. PSP vs AD : Aβ42 (CSF)
  6. AD vs CTRL : NFL (CSF)
  7. CBS vs AD : NFL (CSF)
  8. CTRL vs AD : NFL (CSF)
  9. FTD vs AD : NFL (CSF)
  10. PSP vs AD : NFL (CSF)
  11. AD vs CTRL : YKL-40 (CSF)
  12. CBS vs AD : YKL-40 (CSF)
  13. CTRL vs AD : YKL-40 (CSF)
  14. FTD vs AD : YKL-40 (CSF)
  15. PSP vs AD : YKL-40 (CSF)
  16. AD vs CTRL : sAPPβ (CSF)
  17. CBS vs AD : sAPPβ (CSF)
  18. CTRL vs AD : sAPPβ (CSF)
  19. FTD vs AD : sAPPβ (CSF)
  20. PSP vs AD : sAPPβ (CSF)
  21. AD vs CTRL : tau-p181 (CSF)
  22. CBS vs AD : tau-p181 (CSF)
  23. CTRL vs AD : tau-p181 (CSF)
  24. FTD vs AD : tau-p181 (CSF)
  25. PSP vs AD : tau-p181 (CSF)
  26. AD vs CTRL : tau-total (CSF)
  27. CBS vs AD : tau-total (CSF)
  28. CTRL vs AD : tau-total (CSF)
  29. FTD vs AD : tau-total (CSF)
  30. PSP vs AD : tau-total (CSF)