Jia L, Qiu Q, Zhang H, Chu L, Du Y, Zhang J, Zhou C, Liang F, Shi S, Wang S, Qin W, Wang Q, Li F, Wang Q, Li Y, Shen L, Wei Y, Jia J. Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid. Alzheimers Dement. 2019 Aug;15(8):1071-1080. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (101) |
393 ± 103 pg/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 2011 |
| Aβ42 (CSF) |
CTRL- CNC (101) |
705 ± 152 pg/mL § |
ELISA; Innotest; Fujirebio |
|
| tau-p181 (CSF) |
AD (101) |
82 ± 22 pg/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 2011 |
| tau-p181 (CSF) |
CTRL- CNC (101) |
48 ± 13 pg/mL § |
ELISA; Innotest; Fujirebio |
|
| tau-total (CSF) |
AD (101) |
611 ± 186 pg/mL § |
ELISA; Innotest; Fujirebio |
McKhann et al., 2011 |
| tau-total (CSF) |
CTRL- CNC (101) |
330 ± 96 pg/mL § |
ELISA; Innotest; Fujirebio |
§ Data supplied to Alzforum by author
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