Jongbloed W, van Dijk KD, Mulder SD, van de Berg WD, Blankenstein MA, van der Flier W, Veerhuis R. Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease. J Alzheimers Dis. 2015;46(4):1103-10. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(107)		 432 ± 182
pg/mL		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(67)		 977 ± 208
pg/mL		 ELISA;
Innotest;
Fujirebio
Aβ42
(CSF)		 MCI-AD
(19)		 416 ± 121
pg/mL		 ELISA;
Innotest;
Fujirebio		 Petersen et al., 1999; McKhann et al., 1984
Aβ42
(CSF)		 MCI-Stable
(31)		 710 ± 303
pg/mL		 ELISA;
Innotest;
Fujirebio		 Petersen et al., 1999
tau-p181
(CSF)		 AD
(107)		 90 ± 41
pg/mL		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(67)		 43 ± 15
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-p181
(CSF)		 MCI-AD
(19)		 91 ± 53
pg/mL		 ELISA;
Innotest;
Fujirebio		 Petersen et al., 1999; McKhann et al., 1984
tau-p181
(CSF)		 MCI-Stable
(31)		 62 ± 39
pg/mL		 ELISA;
Innotest;
Fujirebio		 Petersen et al., 1999
tau-total
(CSF)		 AD
(107)		 772 ± 465
pg/mL		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(67)		 243 ± 102
pg/mL		 ELISA;
Innotest;
Fujirebio
tau-total
(CSF)		 MCI-AD
(19)		 771 ± 704
pg/mL		 ELISA;
Innotest;
Fujirebio		 Petersen et al., 1999; McKhann et al., 1984
tau-total
(CSF)		 MCI-Stable
(31)		 401 ± 325
pg/mL		 ELISA;
Innotest;
Fujirebio		 Petersen et al., 1999

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  1. Replication a Challenge in Quest for Alzheimer’s Blood Test

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. MCI-AD vs MCI-Stable : Aβ42 (CSF)
  4. AD vs CTRL : tau-p181 (CSF)
  5. CTRL vs AD : tau-p181 (CSF)
  6. MCI-AD vs MCI-Stable : tau-p181 (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. CTRL vs AD : tau-total (CSF)
  9. MCI-AD vs MCI-Stable : tau-total (CSF)