Clark CM, Xie S, Chittams J, Ewbank D, Peskind E, Galasko D, Morris JC, McKeel DW Jr, Farlow M, Weitlauf SL, Quinn J, Kaye J, Knopman D, Arai H, Doody RS, DeCarli C, Leight S, Lee VM, Trojanowski JQ. Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?. Arch Neurol. 2003 Dec;60(12):1696-702. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(60)		 67 ± 127.8
fmol/mL		 ELISA;
Other/Not Specified;
In-house
Aβ42
(CSF)		 CTRL-
CNC
(73)		 109.4 ± 61.2
fmol/mL		 ELISA;
Other/Not Specified;
In-house
Aβ42
(CSF)		 FTD
(10)		 132.6 ± 117.6
fmol/mL		 ELISA;
Other/Not Specified;
In-house
tau-total
(CSF)		 AD
(60)		 627 ± 446
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 CTRL-
CNC
(73)		 140 ± 97
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 FTD
(10)		 272 ± 120
pg/mL		 ELISA;
Innotest;
Innogenetics

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. FTD vs AD : Aβ42 (CSF)
  4. AD vs CTRL : tau-total (CSF)
  5. CTRL vs AD : tau-total (CSF)
  6. FTD vs AD : tau-total (CSF)