Krut JJ, Zetterberg H, Blennow K, Cinque P, Hagberg L, Price RW, Studahl M, Gisslén M. Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections. J Neurol. 2013 Feb;260(2):620-6. Epub 2012 Oct 9 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : sAPPα (CSF)
- CTRL vs AD : sAPPα (CSF)
- AD vs CTRL : sAPPβ (CSF)
- CTRL vs AD : sAPPβ (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (21) |
488 ± 108 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (43) |
687 ± 203 pg/mL |
ELISA; Innotest; Innogenetics |
|
| sAPPα (CSF) |
AD (21) |
763.9 ± 215.4 ng/mL § |
Electrochemiluminescence; Other/Not Specified; Meso Scale Discovery |
McKhann et al., 1984 |
| sAPPα (CSF) |
CTRL- CNC (43) |
573.7 ± 199.7 ng/mL § |
Electrochemiluminescence; Other/Not Specified; Meso Scale Discovery |
|
| sAPPβ (CSF) |
AD (21) |
480.6 ± 146.7 ng/mL § |
Electrochemiluminescence; Other/Not Specified; Meso Scale Discovery |
McKhann et al., 1984 |
| sAPPβ (CSF) |
CTRL- CNC (43) |
401.7 ± 145.6 ng/mL § |
Electrochemiluminescence; Other/Not Specified; Meso Scale Discovery |
|
| tau-p181 (CSF) |
AD (21) |
97 ± 45 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
CTRL- CNC (43) |
41 ± 21 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (21) |
906 ± 521 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (43) |
263 ± 135 pg/mL |
ELISA; Innotest; Innogenetics |
§ Data supplied to Alzforum by author
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