Ohrfelt A, Grognet P, Andreasen N, Wallin A, Vanmechelen E, Blennow K, Zetterberg H. Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?. Neurosci Lett. 2009 Feb 6;450(3):332-5. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(66)		 370 ± 87
pg/mL §		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(55)		 666 ± 169
pg/mL §		 ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)		 DLB
(15)		 436 ± 121
pg/mL §		 ELISA;
Innotest;
Innogenetics		 McKeith et al., 1999
Aβ42
(CSF)		 PD
(15)		 671 ± 142
pg/mL §		 ELISA;
Innotest;
Innogenetics		 Hughes et al., 1992
tau-p181
(CSF)		 AD
(66)		 99 ± 41
pg/mL §		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(55)		 51 ± 22
pg/mL §		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 DLB
(15)		 52 ± 17
pg/mL §		 ELISA;
Innotest;
Innogenetics		 McKeith et al., 1999
tau-p181
(CSF)		 PD
(15)		 54 ± 10
pg/mL §		 ELISA;
Innotest;
Innogenetics		 Hughes et al., 1992
tau-total
(CSF)		 AD
(66)		 756 ± 277
pg/mL §		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(55)		 310 ± 148
pg/mL §		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 DLB
(15)		 361 ± 148
pg/mL §		 ELISA;
Innotest;
Innogenetics		 McKeith et al., 1999
tau-total
(CSF)		 PD
(15)		 306 ± 65
pg/mL §		 ELISA;
Innotest;
Innogenetics		 Hughes et al., 1992
α-synuclein
(CSF)		 AD
(66)		 317 ± 116
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
α-synuclein
(CSF)		 CTRL-
CNC
(55)		 398 ± 137
pg/mL §		 ELISA;
Other/Not Specified;
In-house
α-synuclein
(CSF)		 DLB
(15)		 312 ± 131
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKeith et al., 1999
α-synuclein
(CSF)		 PD
(15)		 385 ± 169
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 Hughes et al., 1992

§ Data supplied to Alzforum by author

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This paper appears in the following:

News

  1. Still Early Days for α-synuclein Fluid Marker

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. DLB vs AD : Aβ42 (CSF)
  4. PD vs AD : Aβ42 (CSF)
  5. AD vs CTRL : tau-p181 (CSF)
  6. CTRL vs AD : tau-p181 (CSF)
  7. DLB vs AD : tau-p181 (CSF)
  8. PD vs AD : tau-p181 (CSF)
  9. AD vs CTRL : tau-total (CSF)
  10. CTRL vs AD : tau-total (CSF)
  11. DLB vs AD : tau-total (CSF)
  12. PD vs AD : tau-total (CSF)
  13. AD vs CTRL : α-synuclein (CSF)
  14. CTRL vs AD : α-synuclein (CSF)
  15. DLB vs AD : α-synuclein (CSF)
  16. PD vs AD : α-synuclein (CSF)