Song W, Hooli B, Mullin K, Jin SC, Cella M, Ulland TK, Wang Y, Tanzi RE, Colonna M. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimers Dement. 2017 Apr;13(4):381-387. Epub 2016 Aug 9 PubMed.

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Mutations

  1. TREM2 R62C
  2. TREM2 D87N
  3. TREM2 H157Y
  4. TREM2 R62H
  5. TREM2 L211P
  6. TREM2 T66M
  7. TREM2 T96K
  8. TREM2 Q33Ter
  9. TREM2 R47H
  10. TREM2 R52H
  11. TREM2 R136W
  12. TREM2 E151K

Research Models

  1. Trem2-H157Y knock-in
  2. TREM2-IPD
  3. Trem2-IPDxAPP23xPS45
  4. Trem2-H157Y x 5xFAD