Kester MI, Teunissen CE, Sutphen C, Herries EM, Ladenson JH, Xiong C, Scheltens P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM. Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort. Alzheimers Res Ther. 2015 Sep 17;7(1):59. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : VLP-1 (CSF)
- CTRL vs AD : VLP-1 (CSF)
- MCI-AD vs MCI-Stable : VLP-1 (CSF)
- AD vs CTRL : YKL-40 (CSF)
- CTRL vs AD : YKL-40 (CSF)
- MCI-AD vs MCI-Stable : YKL-40 (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| VLP-1 (CSF) |
AD (65) |
182 ± 10† pg/mL |
Single Molecule Counting Immunoassay; Erenna; Singulex, Inc. |
McKhann et al., 1984 |
| VLP-1 (CSF) |
CTRL- CNC (37) |
168 ± 11† pg/mL |
Single Molecule Counting Immunoassay; Erenna; Singulex, Inc. |
|
| VLP-1 (CSF) |
MCI-AD (36) |
233 ± 17† pg/mL |
Single Molecule Counting Immunoassay; Erenna; Singulex, Inc. |
Petersen et al., 1999; McKhann et al., 1984 |
| VLP-1 (CSF) |
MCI-Stable (17) |
136 ± 25† pg/mL |
Single Molecule Counting Immunoassay; Erenna; Singulex, Inc. |
Petersen et al., 1999 |
| YKL-40 (CSF) |
AD (65) |
288 ± 12† ng/mL |
ELISA; Other/Not Specified; Quidel Corporation |
McKhann et al., 1984 |
| YKL-40 (CSF) |
CTRL- CNC (37) |
231 ± 16† ng/mL |
ELISA; Other/Not Specified; Quidel Corporation |
|
| YKL-40 (CSF) |
MCI-AD (36) |
327 ± 19† ng/mL |
ELISA; Other/Not Specified; Quidel Corporation |
Petersen et al., 1999; McKhann et al., 1984 |
| YKL-40 (CSF) |
MCI-Stable (17) |
242 ± 31† ng/mL |
ELISA; Other/Not Specified; Quidel Corporation |
Petersen et al., 1999 |
† Mean ± SEM
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