Clonality: polyclonal
Host: Rabbit
Isotype: IgG
Source: Sigma Aldrich
cat# G9269
References:
Takeda, S, 2010
Damiani, 2008
(unspecified formulation for:
Lee, S, 2010
Marutle, 2007
Lee, JP, 2007
Götz, 2001 )
Formulation: liquid, buffered aqueous solution, IgG fract., PBS, azide
Reactivity:
Reacts in: Human, Rat

Immunogen/Epitope

immunogen = GFAP from human brain

Specificity

GFAP in astrocytes, glia cells (Bergmann glia), gliomasand other glial cell derived tumors

Comments / Questions

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References

Paper Citations

Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7036-41. PubMed.
Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 7;28(19):4878-87. PubMed.
Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010 Nov;177(5):2549-62. PubMed.
Marutle A, Ohmitsu M, Nilbratt M, Greig NH, Nordberg A, Sugaya K. Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12506-11. PubMed.
Götz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5. PubMed.

Antibody

GFAP

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