Wagshal D, Sankaranarayanan S, Guss V, Hall T, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer JH, Rabinovici GD, Rosen HJ, Miller BL, Meredith J, Boxer AL. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):244-50. Epub 2014 Jun 4 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(37)		 237.5 ± 82.7
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(37)		 348.1 ± 75.7
pg/mL		 xMAP;
AlzBio3;
Innogenetics
Aβ42
(CSF)		 PSP
(23)		 269 ± 87
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 Litvan et al., 1996
tau-p181
(CSF)		 AD
(37)		 44.7 ± 25.7
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(37)		 29.1 ± 9.4
pg/mL		 xMAP;
AlzBio3;
Innogenetics
tau-p181
(CSF)		 PSP
(23)		 22.1 ± 7.4
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 Litvan et al., 1996
tau-total
(CSF)		 AD
(37)		 138.4 ± 88.6
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(37)		 79 ± 33.1
pg/mL		 xMAP;
AlzBio3;
Innogenetics
tau-total
(CSF)		 PSP
(23)		 55.9 ± 20.1
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 Litvan et al., 1996

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This paper appears in the following:

News

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. PSP vs AD : Aβ42 (CSF)
  4. AD vs CTRL : tau-p181 (CSF)
  5. CTRL vs AD : tau-p181 (CSF)
  6. PSP vs AD : tau-p181 (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. CTRL vs AD : tau-total (CSF)
  9. PSP vs AD : tau-total (CSF)