Andreasen N, Minthon L, Davidsson P, Vanmechelen E, Vanderstichele H, Winblad B, Blennow K. Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice. Arch Neurol. 2001 Mar;58(3):373-9. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- VaD vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- VaD vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD- Possible Alzheimer's Disease (58) |
572 ± 225 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
AD- Probable Alzheimer's Disease (105) |
523 ± 180 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- Other Controls (18) |
897 ± 242 pg/mL |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (CSF) |
CTRL- Other Controls (18) |
897 ± 242 pg/mL |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (CSF) |
VaD (23) |
704 ± 321 pg/mL |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
| tau-total (CSF) |
AD- Possible Alzheimer's Disease (58) |
699 ± 275 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
AD- Probable Alzheimer's Disease (105) |
759 ± 417 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- Other Controls (18) |
264 ± 102 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
CTRL- Other Controls (18) |
264 ± 102 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
VaD (23) |
461 ± 280 pg/mL |
ELISA; Innotest; Innogenetics |
Román et al., 1993 |
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