Blasko I, Lederer W, Oberbauer H, Walch T, Kemmler G, Hinterhuber H, Marksteiner J, Humpel C. Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias. Dement Geriatr Cogn Disord. 2006;21(1):9-15. Epub 2005 Oct 21 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- DEP vs AD : Aβ42 (CSF)
- AD vs CTRL : MCP-1 (CSF)
- CTRL vs AD : MCP-1 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- DEP vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- ARD vs AD : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- DEP vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (23) |
410.6 ± 60† pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (27) |
866.8 ± 73† pg/mL |
ELISA; Innotest; Innogenetics |
|
| Aβ42 (CSF) |
DEP (11) |
953.3 ± 101† pg/mL |
ELISA; Innotest; Innogenetics |
1991 |
| MCP-1 (CSF) |
AD (23) |
733 ± 44† pg/mL |
ELISA; Other/Not Specified; R&D Systems, Inc. |
McKhann et al., 1984 |
| MCP-1 (CSF) |
CTRL- CNC (27) |
658 ± 85† pg/mL |
ELISA; Other/Not Specified; R&D Systems, Inc. |
|
| tau-p181 (CSF) |
AD (23) |
58.9 ± 8† pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
CTRL- CNC (27) |
22.8 ± 2† pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-p181 (CSF) |
DEP (11) |
28.6 ± 5† pg/mL |
ELISA; Innotest; Innogenetics |
1991 |
| tau-total (CSF) |
AD (23) |
716.6 ± 101† pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
ARD (10) |
607.2 ± 133† pg/mL |
ELISA; Innotest; Innogenetics |
1991 |
| tau-total (CSF) |
CTRL- CNC (27) |
297.1 ± 54† pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
DEP (11) |
221.7 ± 52† pg/mL |
ELISA; Innotest; Innogenetics |
1991 |
† Mean ± SEM
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AlzBiomarker
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- DEP vs AD : Aβ42 (CSF)
- AD vs CTRL : MCP-1 (CSF)
- CTRL vs AD : MCP-1 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- DEP vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- ARD vs AD : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- DEP vs AD : tau-total (CSF)
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