Scientists are honing transferrin receptors to whisk bulky, anti-Aβ antibodies throughout the brain without setting off ARIA and anemia. By halving the effector function of their antibody transport vehicle, Denali researchers blunted red blood cell loss and vascular inflammation, without compromising engagement with Aβ plaques. In a related review, scientists propose rethinking the blood-brain barrier as more a bustling border crossing than a static wall.
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Tweaked, Aβ-Antibodies Cross Blood Brain 'Border' (Bye Bye, Barrier?)
Tweaked, Aβ-Antibodies Cross Blood-Brain ‘Border’ (Bye-Bye, Barrier?)
Far from a static wall, the so-called “blood-brain barrier” is a dynamic, bustling interface that allows select groups of molecules to pass in and out of the brain. Which proteins and nutrients can cross varies according to the needs of the ce...
Reconceptualizing the BBB: Is It Time to Swap ‘Barrier’ for ‘Border'?
The image of the “blood-brain barrier” as a static wall that shields the brain from the rest of the body is crumbling. A group of scientists argue, in a review published in Fluids and Barriers of the CNS earlier this year, that it’s time to ...