CONFERENCE COVERAGE SERIES
Society for Neuoscience Annual Meeting 2018
San Diego, California
03 – 07 November 2018
Toxic Stew of Aβ Dimers Hides Out in Human Plaques
Brains of Alzheimer’s patients contain Aβ dimers consisting of monomers Aβ37 to Aβ42 and held together by covalent bonds.
How Immune Cells From Blood Beget Aging in Brain
At SfN, some scientists described how circulating immune cells deliver aging to the mouse hippocampus; others held off parkinsonism by blocking the effects of eotaxin’s rise in blood. Human trials are starting.
Toxic Tau: Who Are You, and Where Are You From?
Recent conferences revealed that tau is most toxic in oligomeric form, that tau oligomers propagate throughout the brain, and that tau oligomers might harm synapses from within or via astrocytes.
Tau Silences, Aβ Inflames; Hitting Excitatory Synapses Hardest
At SfN and in new papers, scientists describe how synapses crater under the combined onslaught of Aβ and tau. They also link gene-expression signatures to the selective vulnerability of excitatory neurons to tau pathology.
When Glial Clocks Fall Out of Sync, Inflammation Ensues
Disrupting circadian clocks in astrocytes and microglia unleashed harmful responses in these glial cells, leading to neuronal damage.