CONFERENCE COVERAGE SERIES
Alzheimer's Association International Conference 2014
Bella Center A/S, Copenhagen, Denmark
12 – 17 July 2014
Clinical trials, brain imaging, biomarkers, and intervention studies drew more than 4,000 researchers to the Alzheimer's Association International Conference 2014 at the Copenhagen Congress Center in Demark. Data from Phase 2 clinical trials of crenezumab, an anti-Aβ antibody, disappointed, but positive results from a large Finish intervention study raised hope that lifestyle changes can pay dividends toward preventing dementia. The Alzheimer's Prevention Initiative announced a new partnership with Novartis to test if an active Aβ vaccine or a BACE inhibitor can slow or prevent sporadic Alzheimer's in people who are genetically predisposed to the disease. Abstracts for the meeting are freely available here.
Novartis to Partner with Banner Health on ApoE4 Prevention Trial
Novartis Pharmaceuticals Corporation will partner with the Banner Alzheimer's Institute testing experimental preclinical therapies in the upcoming Alzheimer's Prevention Initiative ApoE4 study. The study complements the API ADAD trial.
Crenezumab Disappoints in Phase 2, Researchers Remain Hopeful
At AAIC 2014, crenezumab Phase 2 trial results stirred debate.
Alzheimer’s Disease: In the Eye of the Patient?
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
References and Thresholds—Amyloid Imaging Protocols Debated at AAIC
Could tweaking methodologies improve amyloid diagnosis and tracking?
Anti-Amyloid Therapies Combine Forces to Knock Out Plaques
A mouse study testing the combined effects of a BACE inhibitor and plaque-clearing antibody builds new support for a combination strategy aimed at reducing Aβ buildup in people.
Global Endeavor Underway to Treat Dementia
A global effort to combat dementia has been conducting a yearlong series of events. Alzforum spoke with Dennis Gillings, who chairs the new World Dementia Council.
Falling Dementia Rates in U.S., Europe Hint at Prevention Benefit
New data strengthens the evidence that dementia risk is dropping in developed countries, possibly due to better education and heart health.
Healthy Lives, Healthy Minds: Is it Really True?
Lifestyle changes to evade dementia, such as healthy eating and exercise, made a strong showing at the Alzheimer’s Association International Conference in Copenhagen, Denmark.
Exosomes Stand Out as Potential Blood Biomarkers
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Denied Breakthroughs, Researchers Keep Hunting New Therapies
An active immunotherapy is coming to the fore as researchers continue to try novel therapies.
Scan by Scan, Growing Tau PET Data Picks Up Early Memory Deficits
Does a tau-based early diagnosis look more likely?
Searching for Evidence of Neurodegeneration in the Blood
Researchers continue to screen blood for factors that signal neurodegenerative disease.
Therapies Take Aim at Tau
Researchers are ramping up efforts to target tau for Alzheimer’s and other tauopathies.