Just as Sharp: MRI Scans at Triple the Speed
By utilizing advances in parallel imaging, scientists cut the time needed for diagnostic MRI scans from 18 to 6.5 minutes, without a noticeable loss in quality.
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By utilizing advances in parallel imaging, scientists cut the time needed for diagnostic MRI scans from 18 to 6.5 minutes, without a noticeable loss in quality.
Early stage trials hint that new therapeutics could take down APP, boost ApoE2, or fix inflammatory and metabolic dysfunction in AD.
Vendors of plasma p-tau217-based tests are filing with U.S. and European regulators for approval of fully automated, in vitro diagnostics.
The findings suggest that non-AD pathologies, driven by other comorbidities, might contribute to cognitive decline in these populations.
The commercial software icobrain aria sharpened radiologists’ detection of ARIA-E and ARIA-H. The FDA approved the technology for clinical use November 7.
In Madrid, researchers touted the benefits of plasma prescreening and showed baseline data on these early AD populations. Meanwhile, remternetug has begun Phase 3.
Lilly’s Phase 2 trial of its O-GlcNAcase inhibitor ceperognastat failed to meet clinical endpoints. The drug’s adverse events suggest potential off-target effects.
Bepranemab results bolster hopes for antibodies targeting tau’s middle section. Whether tangle clearance will improve clinical outcomes remains unclear.
ARIA rates have been the same or lower than in the Phase 3 trial. About 9,000 people are being treated in the U.S., half as many in Japan. EMA reverses course, recommending approval.
Trontinemab Data Strengthen Hope for Brain Shuttles Donanemab: Small Tweak in Titration, Big Gain in Safety? Leqembi: Side Effects No Worse in Clinical Use Than They Were in Trial Finally, Therapeutic Antibodies Start to Reduce Tangles Tau Modification Dr
By starting at a low dose and upping it stepwise for four months, scientists nearly halved the risk of ARIA while preserving plaque clearance.
Trontinemab swooped into the brain and removed amyloid efficiently, while causing few cases of ARIA. One person with cerebrovascular pathology died.
Modeling and recombinant protein chemistry suggest that strings of phosphate worm their way through the fibrils. Proof is still needed.
Albala died suddenly while celebrating his 40th wedding anniversary.
Neurons with TMEM106B aggregates lose nuclear TDP-43 in ALS models. In tauopathy models, they accumulate no p-tau.
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