Longevity Through Gut Bacteria? It Works in Worms
Mutations in certain E. coli genes extend the lives of both normal and Aβ-laden roundworms.
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Preventing Dementia: Getting Closer to Recommendations
A review of the latest data hints that blood pressure control, exercise, and cognitive training may preserve memory. But scientists require more convincing before they’ll make concrete recommendations.
APOE4 Subtly Alters Brain Network Activity With Age
In older carriers of the Alzheimer’s risk allele, certain brain regions fail to adapt to increasing task difficulty.
Put ’Em Up: Does α-Synuclein Help Fight Microbes in the Gut?
Biopsies from kids with stomach distress reveal nerve cells that release α-synuclein during infection.
For Better and Worse, TDP-43 Controls Microglia’s Phagocytic Prowess
Microglia lacking TDP-43 efficiently remove Aβ. In the process, they go a little crazy and also attack and destroy synapses.
Human and Mouse Microglia Look Alike, but Age Differently
Transcriptional profiling of human microglia sheds light on species differences, raising caution about translatability of rodent studies.
Barring Export of Expanded Repeat RNAs Tames Their Toxicity
Researchers identified nuclear protein SRSF1 as the culprit that allows aberrant C9ORF72 RNA to escape into cytoplasm and give rise to toxic dipeptide repeat proteins.
TMEM106B and Progranulin Duke It Out at the Lysosome
Knockout mice suggest opposing effects on lysosomal enzymes and neurodegeneration in frontotemporal dementia, implicating an ATPase.
Revised Guidelines for Diagnosing Progressive Supranuclear Palsy
The updated, expanded manual helps doctors diagnose this rare tauopathy and its variants earlier, in hopes that more patients can take advantage of clinical trials.
Retinal Plaques May Enable Noninvasive Screening for AD
In a pilot study, a curcumin-based probe allowed researchers to detect retinal amyloid deposits in AD patients, but it remains to be seen if this can serve as an early biomarker.
Asthma Drugs Suppress α-Synuclein, Reduce Parkinson’s Risk
Agonists of β2-adrenergic receptor dampened transcription of α-synuclein, and protected neurons in mice and patient cells. Norwegians taking the drugs had half the risk of PD.
From Protector to Instigator, Autophagy Makes About-Face in ALS
Autophagy spares motor neurons from synaptic ruin early in disease, but stokes the fires of neuroinflammation later on.
More Evidence that Dementia Case Numbers Are Falling
A birth cohort study in New York City finds a sharp drop in dementia incidence in people born after 1929. Neither better cardiovascular health nor more education explain the data.
Out of Chaos, Order: Reversible Amyloid Structure Seen in Phase Separation
A surprising fold emerges from a low-complexity domain. Videos show core holding steady, N and C termini dancing around.
Intepirdine Joins the Ranks of Failed Alzheimer’s Drugs
In a Phase 3 trial, Axovant’s acetylcholine-boosting drug failed to improve cognition or activities of daily living.
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