Do Astrocytes Blur the PET Signal for ‘Neuronal’ Activity?
In rats, stimulation of astrocytes boosted the signal from micro-FDG PET, suggesting these scans may reflect more than just neuronal activity.
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Touchdown for NfL: Blood Test Tells Parkinson's from Related Disorders
A simple blood draw may help distinguish garden-variety PD from other, less common parkinsonian disorders early in disease.
In New Role for TDP-43, Scientists Say it Controls Protein Synthesis
In cell cultures, excess cytoplasmic TDP-43 shut down global translation and triggered formation of protein inclusions.
Does Soluble TREM2 Rile Up Microglia?
The extracellular fragment of TREM2, but not of its AD variants, promotes microglial survival, activation. To do that, it does not need the full-length TREM2 receptor.
A Change in Sleep Habits from Normal to Long: Harbinger of Dementia?
Going from normal zzzs to sleeping longer than nine hours a night more than doubles a person’s risk of developing dementia, study says.
Blood Neurofilament Light a Promising Biomarker for Alzheimer’s?
The largest study yet on neurofilament light chain suggests plasma levels rise with disease and correlate with other signs of neurodegeneration.
Poly Dipeptide in Cerebrospinal Fluid Marks C9ORF72 Expansion Carriers
Unlikely a disease marker, poly glycine-proline might track therapeutic efficacy in clinical trials.
Childhood Epilepsy Begets Adult Amyloid
People who developed epilepsy as children were more likely to have amyloid in their brains 50 years later, especially if they carried the ApoE4 allele.
Rumblings of Parkinson’s: Gut Microbiome Shifts in Early Stage of Disease
The microbial communities teeming in the intestine of people recently diagnosed with PD differed markedly from those of healthy controls.
Synucleinopathy: How Long You Live Depends on Which One You Have
Examining multiple α-synuclein disorders in a Midwestern population shows that some kill faster than others. The worst: MSA.
Does Presenilin 1 Moonlight as Autophagy Driver, Paradoxically Reducing Aβ?
A phosphorylated version of the protease ramps up autophagy, promoting degradation of the C-terminal fragment of amyloid precursor protein, the source of Aβ.
Analysis of PET Scans Suggests Link Between Amyloid and Tau
An unbiased analysis of positron emission tomography data traces long-distance connections between amyloid and tau pathology in the cortex.
At Risk, or Already Alzheimer’s? Elevated Aβ Predicts Cognitive Decline
Longitudinal ADNI data revealed that people with elevated Aβ declined toward AD, while those with normal levels maintained their cognitive abilities.
More Support for Amyloid Hypothesis: Protective APP Mutation Lowers Aβ in Blood
Study of A673T carriers strengthens case for reducing Aβ to prevent AD.
DLB Guidelines Get a Makeover
New diagnostic guidelines on dementia with Lewy bodies fold in science about sleep and the heart, two aspects that distinguish this disorder from Alzheimer’s and Parkinson’s.
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