Diagnosis for Inflammation in Cerebral Amyloid Angiopathy
Scientists propose and test criteria to detect this treatable disorder without a brain biopsy.
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Purification of Adult Human Astrocytes Shows: They Are Unique
Gene expression analysis highlights differences from mouse astrocytes as well as from immature and cultured human astrocytes.
Cognitive Decline in Young Football Player Tied to Extensive Brain Damage
With the most widespread chronic traumatic encephalopathy yet seen in a player that young, the 25-year-old represents the first published case with neuropsychological data.
Vigorous Exercise: Could it Promote ALS in Women?
Lou Gehrig’s — a name given for good reason? A study supports a correlation between sports and ALS, but it is far from the final word.
PTEN Makes Aβ Depressingly Toxic
Aβ hijacks the neuron’s internal mechanism of synaptic plasticity to tip the balance toward long-term depression. Results suggest a new role for a tumor suppressor protein.
Confirmed: ALS Attacks Cognition and Behavior
A large epidemiological study corroborated previous evidence that rates of both cognitive and behavioral impairment are high in people with amyotrophic lateral sclerosis.
News Brief: More Evidence for Aβ Spread Between People
Scientists found Aβ pathology in the brains of young people who got brain tissue grafts from cadavers. In certain rare circumstances, β-amyloid appears to spread from brain to brain.
Copper to the Rescue in ALS Mice
A compound ensures the ALS-linked protein SOD1 and the respiratory enzyme COX are sated with the essential metal.
Bexarotene—First Clinical Results Highlight Contradictions
The jury is out on whether the drug shifts Aβ in people.
Falling Dementia Rates in U.S. and Europe Sharpen Focus on Lifestyle
Data from the Framingham Heart Study support the idea that dementia incidence is on the decline, but researchers are still dissecting the factors responsible.
Can Common Heartburn Drugs Raise Risk for Dementia?
Older people who regularly used proton pump inhibitors had a greater risk of mental decline.
A Cortical Neuron Circuit Overloads in ALS Model Mice
Overly active interneurons fire up pyramidal neurons in mice with mutant TDP-43.
Truth Will Out: Negative, Confirmatory, Orphan Data Find New Outlets
New online venues welcome data that tend to get the cold shoulder from traditional journals. They offer open peer review and the ability to link papers. Nice try or publishing revolution?
Tau PET Aligns Spread of Pathology with Alzheimer’s Staging
Tracer uptake in the brain matches autopsy data. This opens up new possibilities for in vivo disease staging and longitudinal studies.
Mobile Phone App for Parkinson’s Patients Tests New Model for Data Sharing
Fed up with slow sharing mechanisms, Sage pioneers an end run around primary investigators, and participants opt to share health data with any qualified researcher worldwide.
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