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Make that "blue cheese," a massive protein that is expressed in the CNS of <em>Drosophila</em>. In tomorrow’s Journal of Neuroscience, researchers report that <em>blue cheese</em> mutations are involved in progressive neurodegeneration and the accumulation of protein aggregates...
There is growing interest in the overlap among Alzheimer's disease, Parkinson's disease, and less common synucleinopathies and tauopathies that can share features of both diseases...
Antibodies can be raised that specifically target misfolded prion proteins, leaving native proteins free to carry on their normal functions. This is the conclusion of a paper which appeared in yesterday's Nature Medicine online...
The U.S. Food and Drug Administration has given approval for the drug Stalevo—a cocktail of levodopa (L-dopa), carbidopa, and entacapone—to be marketed in the United States for the treatment of Parkinson's disease...
Human tau—whether normal or a disease-causing mutant—does not make for a healthy <em>C. elegans</em>. In the Early Edition of PNAS, Gerry Schellenberg and colleagues report that both types of transgenic tau lead to behavioral, synaptic, and pathologic abnormalities in the worms...
Parkinson's patients who take medications that block muscarinic cholinergic receptors have increased amyloid plaque and neurofibrillary tangle pathology, according to an article by Elaine Perry of the Newcastle General...
Acetylcholinesterase (AChE), best known for hydrolyzing the neurotransmitter acetylcholine, is also found in the amyloid plaques that plague the brains of Alzheimer's patients. What part this protein has in progression of AD is unclear, but papers suggest...
The September 21 online Nature Neuroscience reports that the serine-threonine kinase Cdk5, which is known to phosphorylate the neurofibrillary tangle protein tau, is essential for ischemia-provoked death of hippocampal CA1 neurons...
A classic case of scientific serendipity has added an ironic wrinkle to the prion story. An article in today's Nature shows intriguing evidence that prions may indeed need nucleic acids to infect hosts-yet these nucleic acids may come from the host itself...
After years as a potential but peripheral suspect in the pathogenesis of Alzheimer's disease, copper (Cu) is lobbying for a new designation—potential therapy! Two studies in the November 17 PNAS Early Edition suggest that copper can...
A paper in the December 5 issue of Science offers some clues about the manifold roles that ROS play in signaling pathways during embryonic development...
Melatonin does not appear to be useful in helping most Alzheimer's patients achieve a good night's sleep, according to a study in the November issue of the journal Sleep...
A report in press in the Journal of Biological Chemistry, published online February 24, adds to the growing body of evidence that traces the etiology of Parkinson's disease to the mitochondria...
A multi-institutional collaboration has vaccinated rhesus monkeys (<em>Macaca mulatta</em>) against the Aβ peptide in an effort to establish a more human-like animal model than mice for use in vaccination studies...
How do Schwann cells know how much myelin to wrap around an axon during development? It's not a trivial problem—a small difference in myelin thickness can change signal transduction speed through the axon, with potentially devastating consequences...
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