Targeting Secretases Reduces Effects of Head Injury
The link between traumatic brain injury (TBI) and dementia may be unclear, but a new study suggests the possibility that the treatment for one may also suit the other...
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More AD Genetics—A Familial Hit from the ADAMs Family
Genomewide association studies reported by two groups converged on three hits for sporadic Alzheimer disease (AD), ApoJ, CR1, and PICALM...
Systems Biology Approaches Get Wnt of Progranulin’s Role in FTD
As much as they can enlighten, microarray analyses also overwhelm...
Synuclein Surprise: Toxicity Linked to Aβ, Plaques?
It may be a bit of a leap, but could α-synuclein toxicity be mediated, at least in part, by amyloid-β (Aβ)?...
Form or Function: How Does Pink1 Deficiency Mar Mitochondria?
Mutations in the Pink1 gene cause a recessive form of early-onset parkinsonism, and all the evidence points to mitochondria as the prime locus of the damage...
Disease Mutations Zip Lock Stress Granules in Proteinopathy, ALS
Researchers report that mutations in hnRNPA2B1 and hnRNPA1 cause amyotrophic lateral sclerosis and multisystem proteinopathy...
Does Estrogen Put the Brakes on Aging in ApoE4-Positive Cells?
White blood cells age quickly in post-menopausal women who carry the ApoE4 gene, but estrogen slows that decline...
Can Phagocytosis, Memory Effects Revive Diabetes Meds?
The diabetes drugs rosiglitazone and pioglitazone once looked promising for AD, until rosiglitazone failed in Phase 3. But have reports of their death been exaggerated?...
Prague: N-terminal APP Story Buzzes in the Hallways
A story that broke at Keystone last month strongly pervaded the 9th International AD/PD conference in Prague...
Disputing the Dismuting—What Is the Real Role of SOD in ALS?
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons of the central nervous system. Though its biology is poorly understood, one controversial theory suggests that oxidative damage...
NO Laughing Matter—Nitrosylation of Isomerase Spells Trouble for Neurons
If the number of diseases associated with protein aggregates is anything to go by, keeping...
Promoter Bashing—Mitochondrial Ones Damaged in AD Brain
Recently, scientists reported that certain human promoter sequences are more susceptible to age-related mutagenesis, suggesting that...
In C. Elegans, Aspartyl Proteases and Calpain, Not Caspases, Play the Grim Reaper
The proteolytic degradation that accompanies neurodegeneration in animals may be mediated not by apoptotic proteases, but by a group of aspartyl and calcium-dependent proteases, at least in the roundworm, researchers report in today's Nature...
Lack of Lipoprotein Receptor Boosts Brain ApoE, but Not Aβ
ApoE figures large in Alzheimer disease as the only known genetic risk factor for sporadic AD and an important regulator of...
Join the Quantum Dots—for Brighter, Longer, and Multiplex Cell Images
Scientists keen on monitoring cellular events in real time can now add another imaging technique to their repertoire—the use of quantum dots...
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