The Theology of Aβ: Presenilins Giveth, and They Taketh Away
Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show...
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GSK3β—Not Just for Tauists Anymore
Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that features...
Research Brief: Assessing Aβ Oligomers Toxicity in Live Mice
This, that, and the other form of Aβ have shown themselves harmful to neurons in various settings, but debate continues to rage over which are most menacing in Alzheimer’s disease...
Keystone Drug News: Glimpse of Lilly’s Phase 1 Passive Vaccine
Antibody therapies for AD have galvanized researchers and affected families and observers from academia, industry, and even the investment community...
RNA Twist: C9ORF72 Intron Expansion Makes Aggregating Protein
Since the identification of the major ALS and FTLD gene C9ORF72 more than a year ago, scientists have been hunting for clues as to how it promotes disease...
Alzheimer Study Group Complete—To Start Its Work
The Alzheimer Study Group is a non-partisan panel led jointly by former Speaker of the House Newt Gingrich and former U.S. Senator Bob Kerrey...
Tau Toxicity—Tangle-free But Tied to Inflammation
The toxicity of neurofibrillary tangles has been hotly debated even though...
Plaque Microglia—Mobile But Limited
In the April 16 Journal of Neuroscience, researchers give a vivid account of the microglia/plaque relationship...
New Parkinson's Fly Can’t Fly, Implicating Mitochondria
Mitochondrial malfunction underlies the pathological damage seen in fruit fly models of Parkinson's disease, researchers report in this week's PNAS online. The paper adds to the growing body of evidence linking this intracellular organelle to neurodegeneration...
Seeing Is Believing—Plaque Growth Is Slow, Tapers With Age
To understand how amyloid plaques, the troublesome clumps of Aβ, form and grow in the brain, it helps to just watch the action directly...
Neurogenesis Gets a Jolt From Enhanced APP Processing, Curcumin
The birth of new neurons in the adult brain intimates a capacity for restoration even in the face of aging and neurodegeneration...
Garbage BAG2 Takes Out the Tau
Cells have more than one way to get rid of tau, the tangled protein in the brains of people with Alzheimer disease...
Highs and Lows: Overactive Synuclein Promoter Linked to Parkinson’s, Tau Loss to Mental Retardation
Mutation or duplication of the protein coding sequence of the α-synuclein gene (SNCA) can cause autosomal dominant inherited Parkinson disease, but...
Survivor ALS Models—Immunity Protects Against Mutant SOD
Recent evidence points toward glia as cells gone terribly wrong in promoting the pathology that drives amyotrophic lateral sclerosis...
Tuebingen: Researchers Reminisce, Predict at Alzheimer Centennial
On Saturday, 3 November, 1906, Alois Alzheimer traveled from Munich, where he lived and worked, to Tuebingen. That afternoon...
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