AICD—Salute to Salutary Effects
Amyloid-β (Aβ) precursor protein (APP) has something of a mixed reputation...
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Philadelphia: Targets in a Barely Tapped Market Keep Big Pharma Focused on AD
At the l7th Annual Marian S. Ware Neurodegenerative Diseases Research Retreat, hosts Virginia Lee and John Trojanowski pulled together a formidable roster of speakers...
Search and Rescue in Parkin Fly Mutants—DA Neurons Are Lost, but Saved by GST
Two years ago, researchers succeeded in breeding fruit flies with mutations in parkin, the gene responsible for most cases of early-onset PD in humans...
Why Good Microglia Turn Bad—A Matter of Timing?
The accumulation of phagocytic microglia in the brain could be good or bad for AD patients...
Dementia Risk Increases, at Least in Those Who Start Hormone Therapy Late
In sharp contrast to prevailing hypotheses, taking combination hormone replacement actually doubles a woman’s risk of developing dementia, including Alzheimer's disease, when the therapy is begun at age 65 or older...
Stress and Trauma: New Frontier Lures Alzheimer’s Researchers
The wars of the last decade have highlighted the effects of traumatic brain injuries (TBIs) and post-traumatic stress disorder (PTSD)...
ApoA1: Does Good Cholesterol Protect the Brain?
What’s good for the heart may be good for the brain...
Synaptic Rescue—Lowering Kinase Activity Sends Fragile X Symptoms PAKing
Following a recent report linking Fragile X mental retardation protein (FMRP) with...
Yeast Screen Implicates PARK9 in Synuclein Toxicity
In Parkinson disease, death of dopaminergic neurons can result from mutations in one of several genes, environmental factors, and unknown causes...
Macrophages Storm Blood-brain Barrier, Clear Plaques—or Do They?
Blocking the signaling of TGF-β in peripheral macrophages allowed those immune-system scavengers to enter the brain and clear amyloid deposits...
Thanks for the Memories—KIBRA Alleles Predict Top Memory Performers
If you are one of those people who can recall verbatim a conversation held a year ago, then you might want to thank...
AD Research Participation: Informed Consent Complicates Trials, Part 2
There is an inherent dilemma in how best to ensure protection for cognitively vulnerable subjects without impeding research...
Synuclein Modifications: Caveat Emptor With Those Phosphomimetics
When good proteins go bad in neurodegenerative diseases, the road to ruin often runs through modification and via aggregation to toxicity...
Presenilins, Ryanodine Receptors—Conspirators in Neurotransmission?
Presenilin mutations cause familial Alzheimer disease, but just how they do their damage is not understood...
Good Gene, Bad Gene?—New APP Variant May Be Both
Scientists have discovered a recessive mutation in β amyloid precursor protein that causes early-onset Alzheimer disease in two siblings from a small south Italian village...
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