APP Sorting Protein May Link Alzheimer’s and Diabetes
Two pernicious disorders of late life, Alzheimer disease and diabetes, may be tied together...
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Vienna (and Burkina Faso): What's New With Methylene Blue?
This story presents an update from this year's ICAD conference, together with an extended Q&A with the developer of RemberTM, Claude Wischik...
Tau’s Synaptic Hats: Regulating Activity, Disrupting Communication
What does the axonal protein tau have to do with synapses? Quite a bit, some scientists say...
Corrupt Code: DNA Repeats Are Common Cause for ALS and FTD
Meet C9ORF72. Researchers have found that über-long repeat expansions in this uncharacterized gene cause ALS and FTD...
News Brief: ALS Drug Olesoxime Fails in Phase 3 Trial
The ALS drug olesoxime failed to achieve the desired survival effect in a Phase 3 clinical trial...
New Kid on the Block: Nicotinic Receptor Sensitive to Aβ
There’s a new player in town or, to be precise, in the rat brain...
GABA and Plasticity—Can Antagonists Improve Cognition?
Boosting neuronal excitation with acetylcholinesterase inhibitors is one way of tackling cognitive decline in Alzheimer disease...
Memantine Wins FDA Approval
The FDA last Friday followed the recommendation of its advisory panel last month and approved memantine for use in moderate to severe AD...
Less VAPid Now: Role for ALS Protein Gets Substance
Scientists are beginning to get a handle on a rare inherited form of amyotrophic lateral sclerosis (ALS)...
Being Pleasantly Plump: Way to Live Longest with ALS?
Researchers report that a high body mass index (BMI), indicating mild obesity, was linked to survival in ALS...
Histone Acetylation: Epigenetic Achilles’ Heel of Memory in Aging
Several recent studies have shown that memory formation, learning, and age-associated cognitive decline are linked to remodeling of chromatin proteins...
New Clinic Offers One-stop Shopping for All Your Cognitive Needs
A new kind of cognitive clinic, which opened 6 March in Santa Barbara, California, aims to help people stay mentally sharp by addressing mind, body, and soul...
APP in Pieces: βCTF implicated in Endosome Dysfunction
The Aβ peptide claims the lion’s share of attention from researchers, but lately, other metabolites are grabbing the spotlight as potential purveyors of pathology...
Do Overactive Brain Networks Broadcast Alzheimer’s Pathology?
Scientists have long wondered why certain brain regions bear the brunt of Alzheimer’s disease...
Committee Shoots Down Florbetapir, Raising Bar for Field at Large
An FDA Advisory Committee today voted to reject Avid Radiopharmaceutical’s New Drug Application for their amyloid imaging agent AV-45/florbetapir/Amyvid...
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