Can Heparin Delay Alzheimer’s Disease?
In two hospital systems, people who received heparin were diagnosed with AD a year later than people who never took the anticoagulant.
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Donanemab Data Anchors Upbeat AAIC
Alzheimer’s researchers got their first look at data from the positive Phase 3 trial. Many expect this antibody to become the third approved immunotherapy for AD.
CSF MTBR-tau-243 Tracks Tangles, Plummets in Response to Antibody
In contrast to phospho-tau species that mirror amyloid, CSF MTBR-tau-243 reflects tau-PET. It fell upon treatment with an antibody against tau’s midsection.
Gantenerumab Prevention Trial in Sporadic Alzheimer's Begins
Taking a stab at secondary prevention, the four-year Phase 3 trial will assess the antibody’s ability to slow slippage in 1,200 cognitively healthy, amyloid-positive people.
'Presymptomatic AD' or 'Asymptomatic at Risk'? Dx Criteria Disagree
Alzheimer’s Association diagnostic criteria favor the former term, International Working Group the latter, for cognitively healthy people with AD biomarkers.
X-Chromosome-Wide Association Data Spot Alzheimer’s Loci
XWAS from three research groups identified a dozen genetic loci that may help explain sex differences in AD.
Can Human Cytomegalovirus Infections Spark Alzheimer’s Pathology?
In postmortem tissue, nearly half of AD patients had HCMV infections in the brain and gut. In cerebral organoids, HCMV triggered accumulation of Aβ and p-tau212.
Bile Acid: An Elixir of Youth?
In lab animals, lithocholic acid replicates life-extending benefits of caloric restriction.
Plaques Spur Spread of Tangles by Sending Synapses into Overdrive
Hyperconnectivity ushers tangles from temporal lobe to posterior cortex. Study could revive interest in trialing anti-convulsants with tau biomarkers as an outcome.
C-Terminal Amidation Sends Proteins to the Shredder
Triggered by oxidative stress, this degradation signal may protect neurons.
From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
Mice have a small pool of such Tregs. Removing them hobbles the hippocampus, beckons immune invasion, revs glia, and quashes neurogenesis.
Proteomics Lays Groundwork for FTD Biomarkers
Surveys of CSF proteins from the GENFI and ALLFTD genetic cohorts flag altered biological processes and point toward FTD fluid markers.
One-Shot Deal? Mice Regain Memory Day After Vaccination, Plaques Stay Put
The first clinical trial may be dead, but AD vaccination research is alive and kicking...
Insulin-Degrading Enzyme Not, After All, a Risk Factor for AD?
At the Society for Neuroscience meeting last November in San Diego, the Alzheimer Research Forum reported on insulin-degrading enzyme as a potential risk factor for late-onset Alzheimer's disease...
New Insights and Strategies for Treating PolyQ Disorders
A flurry of recent papers is shedding new light on the role of proteins containing expanded polyglutamine tracts (polyQ) and their molecular partners, bringing researchers a small step closer toward understanding...
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