RIKEN Says Its Mouse Models Are Now Easier to Obtain
Fewer requirements and simpler agreements should improve accessibility, use.
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As Health Problems Pile Up, Dementia Climbs on Top of the Heap
According to findings from more than 200,000 people 60 and older, having multiple chronic diseases nearly doubles the risk of dementia within the next 12 years.
Scientists Say It's Time to Update ATN Criteria
In this classification scheme, T, i.e. tau, means different things. Phospho-tau predicts tangle buildup, whereas tau-PET signals neurodegeneration and cognitive decline.
How Will Alzheimer’s Trials, Treatment Change in 2023 and Beyond?
With lecanemab likely to garner FDA approval next year, Alzheimerologists are pondering how clinical practice, and their science, will be transformed.
ALS/FTD Genes Converge on Endolysosomal System, Stoking TDP-43 Pathology
TANK-binding kinase 1 gets wrapped up in poly-GA aggregates translated from C9ORF72. TDP-43 aggregation ensues.
Defining Biomarker Curves, Progression Models for Familial FTD
Data from two large international familial cohorts predict disease onset, helping researchers select the best participants for secondary prevention trials.
Perivascular Macrophages: New Target in Aging and Alzheimer’s Disease?
These unassuming cells keep cerebral vessels supple, forcing CSF through the brain and clearing Aβ. Their abilities wane with age, but can be restored.
Meddling Medin: A Vascular Amyloid That Promotes CAA?
In mice, this glycoprotein fragment accelerated amyloid deposition in cerebral blood vessels; in people, higher levels correlated with faster cognitive decline and greater AD risk.
Short Aβ Fibrils Easily Isolated from Alzheimer's Brain Fluid
Once assumed to be high-molecular-weight oligomers, these short, diffusible fibrils share the same structure as their plaque-bound counterparts. Both bind lecanemab.
FDA Approves Fujirebio’s CSF Test for AD—Quest Diagnostic Offers Plasma Test
The first FDA approval of a CSF test, and increased options for plasma testing, will give patients easier access to these diagnostic aids. Will physicians interpret them properly?
Lewy Body Dementia Shares Risk Genes with Alzheimer’s, Parkinson’s
Whole-genome sequencing combined with expression data identifies five LBD loci: three known and two new. Four increased LBD risk while one appears protective.
Meddling Microbiome Worsens Tauopathy and Neurodegeneration
Sex and ApoE genotype influenced the function of the millions of microbes that colonize the mouse gut. Short-chain fatty acids appear to carry messages from bacteria to cytokine-producing cells.
Aged Astrocytes Prime Brain for Neuroinflammation
Two transcriptional profiles of astrocytes in healthy old mice record a surge in reactive and inflammatory gene expression.
Hyperconnectivity in Cingulate Precedes Amyloid. Astrocytes to Blame?
Years before plaques develop in AD, the cingulate cortex brims with excess activity. Ditto in APP knock-in mice, where listless astrocytes allow a neuronal frenzy. Do astrocytes play into the pathological cascade this early?
First Primate Model of Familial AD: Marmosets with Presenilin Mutation
Three young monkeys missing exon 9 of presenilin 1 seem to have an elevated Aβ42/40 ratio. It remains to be seen if they will develop plaques and tangles as they age.
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