Map of Human Vascular Expression Highlights its Potential Role in Alzheimer’s
The first detailed look at expression profiles in blood vessels of the human brain identifies new cell subtypes. These cells express 30 of the top 45 AD risk genes.
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New Knock-In Mice Rapidly Accumulate Amyloid Plaques
The APP/PS1 double knock-ins begin to deposit amyloid in the brain by 3 months of age.
iNDI Aims to Standardize Human Stem Cell Research
The iPSC Neurodegenerative Disease Initiative is creating 100+ isogenic cell lines. Each carries a different risk variant for Alzheimer's or a related dementia. Scientists around the world can obtain the cells through Jackson Labs.
Forget Typical Alzheimer's: AI Finds Four Types.
Machine learning analysis of 912 PET scans says neurofibrillary tangles spread through the AD brain in one of four distinct patterns.
Does Anti-Amyloid Immunotherapy Need the Lymphatic System?
The fewer their meningeal lymphatic vessels, the slower treated mice clear plaques. Lymphatic dysfunction also drives microglial activation, hinting at a role in pathology.
Diabetes in Mid-Life Drives Up Dementia Risk
People who develop Type 2 diabetes before age 60 have more than double the dementia risk, and earlier dementia onset, than those without diabetes.
Sans Nuclear TDP-43, Splicing of An ALS/FTD Gene Goes Awry
Incorporation of a cryptic exon scuttles translation of UNC13A, but only in neurons lacking nuclear TDP-43. UNC13A ALS/FTD risk variants exacerbate the aberrant splicing.
Bio-Hermes: Making Alzheimer’s Diagnosis Fast, Cheap, Accessible
A new trial will compare digital and blood-based biomarkers to amyloid PET scans in order to learn which ones best pick out early plaque accumulation.
Proteomics Dates Endosomal, Synaptic Changes to Preclinical AD
In postmortem brain, proteins involved in all manner of vesicular functions waxed or waned with increasing phases of disease, starting years prior to symptoms.
Microglia Build Plaques to Protect the Brain
Instead of chewing up and disposing of the amyloid they ingest, microglia appear to compact it, then spit it back out as dense-core plaque.
In Pilot Study, Electric Therapy Improves Memory
Sending low-intensity, gamma frequency electric current through the brain boosted short-term memory, perhaps by increasing cholinergic transmission.
More Data on Herpes and Alzheimer’s Disease
Herpes infection upped risk in ApoE4 carriers, damaged brain tissue, and correlated with neurodegeneration markers in the CSF.
Tau, Speckle Wrecker, Disrupts the Nuclear Home
Disruption of the membraneless organelles may explain toxicity of tau aggregates.
Does Re-entering the Cell Cycle Help Neurons Survive?
In cell culture, neurons with the strongest expression of cell-cycle proteins survived best in the presence of Aβ oligomers.
Does Synchronizing Brain Waves Bring Harmony?
In early stage trials, light and sound promoted neuronal communication, calmed immune cells, and slowed brain atrophy, but cognitive benefit remains unclear.
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