Potential NGF Drug-Delivery System
Puny polymer pellets show promise as a vehicle for delivering nerve-growth factor (NGF) to the basal forebrain, where the substance could rescue or even regenerate neurons damaged by Alzheimer's disease...
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Gene Locus Found for Schizophrenia Risk
A 15-year study involving more than 100 families and 1,000 individuals has provided the first strong evidence of genetic susceptiblity to schizophrenia, within a stretch of chormosome 13...
Yin and Yang of Nerve Cell Growth
The growing tips, or growth cones, of neurons are confronted with a chemical cacophany of growth-guiding cues. How do they know which ones to heed?...
Epilepsy Drugs Effective for Agitation in AD
For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients frequently exhibit...
Stress Hormones Impair Recollection
Stress and glucocorticoids (hormones produced in response to stress) are known to impair the acquisition and storage of new information. But stress also hinders the ability to recall memories...
Membrane Rafts Revealed
It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs)...
Resisting Apoptosis
Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis...
Cholinergic Switching
Acetylcholine has different effects on the excitability of different neuronal types, according to work by Xiang, et al, published in today's Science. The researchers examined two subtypes of interneurons in layer V of rat visual cortex...
More Clues to Diet and Aging
Maybe it is time to give up steak in order to live longer—at least if you are a fruit fly. According to a study published today in Science, a diet of sugar keeps flies in a metabolic "waiting mode," in which both reproduction and death rates are low...
Enzyme Affects Aging Rate
An enzyme in <em>Caenorhabditis elegans</em> affects the rate at which the dainty worms age, by modulating the cellular response to oxidative stress...
Sixth Int. Conference on AD: Presenilin-binding Proteins Abound
Because presenilin was discovered in positional cloning experiments involving large familial Alzheimer's disease kindreds, there were no previous data concerning its biological function. As a result...
Sixth Int. Conference on AD: Search for Late-Onset AD Genes
A study published last year by Margaret Pericak-Vance et al. (JAMA 1997;278) reported a putative locus for late-onset Alzheimer's disease (LOAD) at chromosome 12p11-12, and set off a race to confirm and nail down the gene...
Sixth Int. Conference on AD: Aging Astrocytes: A Role in AD?
Yamaguchi (Abstract 1245) presented his theory that very diffuse plaques within nondemented individuals are cleared by astrocytic phagocytosis. He showed many examples of very diffuse Aβ-positive staining...
Sixth Int. Conference on AD: Scientists Smitten by Mad Tau Disease
A new epidemic of "mad tau disease" swept Amsterdam at the workshop on Hereditary Fronto-Temporal Dementia and Pick's disease. Fronto-temporal dementia and Parkinsonism linked to chromosome 17...
Sixth Int. Conference on AD: Fibril-busting Mystery Herb
While a number of drug companies have been pumping big bucks into creating novel molecules capable of inhibiting formation of Aβ fibrils, along comes Alan Snow and his colleagues...
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