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Less than two weeks after announcing that memantine had shown significant benefit in a clinical trial of patients with moderate to severe Alzheimer's disease, Forest Laboratories announced that they have withdrawn their New Drug Application with the FDA...
Fluorescence imaging has become a powerful tool for measuring protein mobility and is particularly suited to probing the dynamics of protein-protein interactions in inclusion bodies....
A trio of papers introduces new optical tricks for manipulating gene expression and activating fluorescent reporters...
Researchers from The Jackson Laboratory and Tufts University report that oxidative stress is linked to cell-cycle re-entry and neurodegeneration in a mouse expressing abnormally low levels of the apoptosis-inducing factor (Aif) gene...
Forest Laboratories, Inc., reported last week that patients with moderate to severe Alzheimer's disease taking memantine and donepezil had significant improvement over patients on donepezil alone on tests of cognitive and daily functioning...
Researchers working on NSAIDs as potential treatments for AD are discussing whether a large ongoing prevention trial of two such anti-inflammatories is testing the right drugs.
Convergent biochemical and genetic evidence indicate that the main component of Alzheimer's plaques, the amyloid β peptide (Aβ), plays an initiating role in a complex cascade that culminates in dementia and ultimately death (1,2).
During his lifetime, Alois Alzheimer described five cases of the “characteristic sickness of the cerebral cortex” that his boss, the eminent psychiatrist Emil Kraepelin, later would name in honor of his late colleague. Now, neurologists in Alzheimer’s home state of Bavaria are investigating how these early patients’ family members fared. One patient, Johann F., turns out to have belonged to a large clan afflicted with an early-onset, heritable form of the disease. Many descendants still live in Bavaria, some in the U.S.
Viral vectors are an effective means to deliver small interfereing RNAs into target cells and organs in vivo, according to University of Iowa researchers. The authors demonstrated the therapeutic potential of this technique by inhibiting the expression, in neural cell lines, of eGFP chimeras that contained a polyglutamine (polyQ) tract.
The Notch signaling pathway is of considerable interest to those studying Alzheimer's disease because the Notch receptor and the amyloid-β precursor protein (AβPP) are proteolytically processed much the same manner. Now the Notch pathway may contribute to the progression of another neurodegenerative disease, multiple sclerosis (MS)....
Conference Report "Cell and Molecular Biology of Alzheimer's Disease" Cell and Molecular Biology of Alzheimer's Disease
Read Peter Davies’ summary of this meeting, organized by Eva-Maria Mandelkow and Ulrike Beisiegel.
Previous studyies have indicated that Aβ somehow impairs long-term potentiation, but what are the signal transduction pathways involved in this phenomenon? A paper from Michael Shelanski's lab suggests as a candidate pathway involved in memory formation.
How similar are neural stem cells to their hematopoietic brethren? Two parallel gene expression studies compare the two.
A specific apoptosis pathway is being advanced to account for the selective death of motorneurons in ALS. Also mysterious is what causes the selective neuronal death of cholinergic neurons in Alzheimer's and dopaminergic substantia nigra neurons in Parkinson's. Could this study point to new possible explanations?
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