Necroptosis Rampant in the Alzheimer’s Brain?
Markers of necroptosis peppered postmortem brain tissue from people with AD. Gene expression implicates RIP kinases. Could shuttering this cell death pathway save neurons?
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Do APP and Parkinson’s Proteins Collude to Cause Neurodegeneration?
One report implicates APP’s intracellular domain in neuron loss due to LRRK2; another accuses the AICD fragment of regulating mitochondrial dynamics via Pink-1.
Phosphorylation of FUS Does Away with Droplets
FUS proteins tend to link up and form liquid droplets and, from those, aggregates. Phosphorylation of the protein’s low-complexity domain repels these associations.
The Search for the Missing AD Heritability Turns Up New Rare Variants
High-throughput sequencing yields surprises. Learn about pathogenic variants in endosomal genes, an algorithm to nab the worst SORL1 mutations, dominant PS1 mutations arising de novo, and tau duplications.
All Signs Point to Tau Tangles as the Culprit in Fading Memory
Researchers at AAIC reinforced the idea that tau pathology drives cognitive decline, although amyloid plaques were implicated in semantic memory deficits.
CSF and Brain Markers Highlight Different Facets of Dementia
Researchers at AAIC described different correlates of CSF and PET measures of Aβ and tau.
Shot of Klotho Boosts Memory In Aging and Diseased Mice
Injecting a piece of this anti-aging protein days before memory testing improved performance in mice young and old, as well as those that overexpress α-synuclein.
New Ties between AD and the Stages, Waves, and Molecules of Sleep
At AAIC 2017, scientists offered new clues on sleep and AD neuropathology. They identified parts of the brain that may be involved and highlighted the benefits of treating sleep disorders.
Data from DIAN Revise Familiar Biomarker Trajectories
Rather than changing one by one, many biomarkers—including cognition, tau PET, hippocampal atrophy, and CSF p-tau—shift together, around the time of symptom onset in young adults with familial AD.
Longitudinal Data Say: Nope, CSF Markers Do Not Track Progression
AAIC presentations identified early imaging changes in aging and AD, and reinforced the idea that CSF markers change little over the short term.
Stress Relief Helps Neurons in Alzheimer’s, ALS
Tamping down a cell stress response saves neurons from degenerating while helping mice retain both their strength and their wits.
Aha! Co-Conspirator Caught Misfolding Tau
Hsp90, a protein chaperone that helps misfold tau, enlists the co-chaperone Aha1 in the process. Could crippling Aha1 reduce tau aggregation?
Teasing Out the Brain Features Behind Cognitive Reserve
Researchers at AAIC presented several imaging measures that may help explain the phenomenon of preserved cognition in the face of AD pathology.
At AAIC, Yet Another Phase 3 Flop While Phase 1 Trials Forge Ahead
Idalopirdine is out. Next up, a handful of secretase inhibitors, other small molecules, and immunotherapies for Aβ and tau seem safe in Phases 1 and 2.
At AAIC, Encouraging Safety Data on a Variety of Small-Molecule Candidates
Three BACE inhibitors, a γ-secretase modulator, and a phosphodiesterase inhibitor appeared safe in Phase 1 trials.
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