Do Smartphones Collect Better Clinical Data Than Paper-and-Pencil Tests?
A trial of an α-synuclein antibody is making use of the technology to follow subtle changes in the day-to-day function of participants.
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α-Synuclein Antibodies Enter Phase 2, Sans Biomarker
Even without this important sidekick at hand, scientists are forging ahead with efficacy trials of their first attempts at disease-modification in Parkinson’s
FDA Approves Edaravone for Treatment of ALS
The drug slows functional decline in patients with mild disease and should be available to U.S. patients in August.
Non-Amyloid Treatments: Inflammation, Epigenetics, Regeneration
A broadening drug development pipeline now contains Phase 1 or 2 drugs on targets unrelated to Aβ or tau.
Olfactory System Model Explores Antimicrobial Role for α-Synuclein
Preparing the whole mouse head—not just the dissected brain—lets researchers analyze the neural tissue outside the skull that connects the nose to the inner sanctum.
Anti-Amyloid Drug Pipeline Shows No Sign of Drying Up
Researchers at AD/PD 2017 presented new data on an antibody and small molecules targeting amyloid.
What Price Success? Ionis Drug Worked in Phase 3 but Had Serious Side Effects
Ionis announced top-line results of a Phase 3 trial of their drug for familial amyloid neuropathy. It met both primary endpoints but caused serious side effects in some people.
Stimulating Specific Neurons Mobilizes Dopamine-Depleted Mice
By targeting distinct cell populations in the external globus pallidus, researchers restore mobility to a mouse model of Parkinson’s disease.
Certain Cancer Drugs Held Out as Prospects for ALS Therapy
Tyrosine kinase inhibitors kept diseased motor neurons alive in vitro, and notched positive findings in a recent Phase 3 trial. A new paradigm for ALS treatment?
Alzheimer’s Deaths on the Rise
Over the past 15 years, deaths attributable to Alzheimer’s have risen 55 percent, according to the CDC, and more people are living at home when they die, suggesting a need to support caregivers.
Phase Transitions in Biology and Disease
Protein Liquid-Liquid Phase Transitions: The Science Is About to Gel Confused about protein liquid-liquid phase transitions? You are not alone. Researchers working in this emerging field gathered in Leuven in early May to make sense of the latest data lin
Paper Alert: TREM2 Crucial for Microglial Activation
Immune cells lacking the receptor fail to respond to injury and aging, resulting in overall poor brain health in mouse models.
Astrocytes, In Addition to Neural Networks, May Stoke Synuclein Pathology
Injected α-synuclein fibrils triggered pathology throughout the mouse brain, even in regions not neuroanatomically connected to the injection site. Astrocytes were loaded with inclusions.
Familial ALS Linked to Both Neuron and Astrocyte Pathology
In a human cell model, VCP variants trigger a cascade of neuronal disruption and hobble astrocytes’ ability to support motoneurons.
ALS/FTD Genes Reveal Pathways to Pathology
CHCHD10 mutations target mitochondria and TDP-43, while a UBQLN4 allele hits the proteasome.
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