Vascular Disease in 50s Begets Brain Amyloid in 70s
Prospective study links cardiovascular risk factors to brain amyloid.
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Are CSF Assays Finally Ready for Prime Time?
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.
ApoE and Tau: Unholy Alliance Spawns Neurodegeneration
In tauopathy mice, ApoE4 hastened neuroinflammation and neurodegeneration. No amyloid involved. (Tip: Think A1 astrocytes.)
AD/PD 2017 Draws Record Number of Scientists To Vienna
Next-Generation Tau PET Tracers Strut Their Stuff Are CSF Assays Finally Ready for Prime Time? ApoE and Tau: Unholy Alliance Spawns Neurodegeneration New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response Location, Conformation, Decoration: Tau
New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response
The receptor responds to brain insults such as oligomeric Aβ and cellular debris by jolting microglia into clean-up mode, according to researchers at AD/PD 2017.
Umbilical Cord Blood Tied to Hippocampal Rejuvenation
TIMP2 and possibly other human plasma proteins reinvigorate aged hippocampi in mice.
Yaffe and Kawas Share 2017 Potamkin Prize
For their work on modifiable dementia risk factors and dementia in the oldest old, respectively, Kristine Yaffe and Claudia Kawas split this year’s coveted award in neurodegeneration research.
Put Down That Pop: Sweet Drinks Tied to Stroke, Dementia
Need another reason to grab water instead of a soda? Beverages with added sugar—natural or artificial—are linked to smaller brain volume, worse memory, and tripled odds of stroke and dementia.
Location, Conformation, Decoration: Tau Biology Dazzles at AD/PD
Showcasing forays into the biology of tau, researchers at AD/PD reported news on tau’s transcriptional regulation, its bungling of synaptic vesicles, its sway over the epigenome, and even flashed an atomic structure.
NIH Summit Examines What Makes a Healthy Aging Brain
As the brain ages, what protects it from cognitive decline? A two-day conference focused on reserve and resilience.
Look in the MiR: MicroRNA Fans Neurogenesis in Old Alzheimer’s Mice
Overexpressing miR-132 dampened AD pathology in young mice, and appeared to nourish the birth of new hippocampal neurons in older animals.
Cognitive Aging Summit III
NIH Summit Examines What Makes a Healthy Aging Brain
Transcranial Magnetic Stimulation for AD Boasts Success in Phase 3
Manufacturers of a therapy system called neuroAD, which combines transcranial magnetic stimulation with cognitive training, are applying for FDA marketing clearance.
Treating Tau: Finally, Clinical Candidates Are Stepping into the Ring
Three anti-tau antibodies are in Phase 1 or 2, while an O-GlcNAcase inhibitor got the green light to start testing.
Two For One? ASOs for Ataxin Allay ALS and SCA2 in Mice
Using torpedo-like DNA snippets to delete mRNAs from cells, scientists lowered the amount of ataxin-2 protein. This allayed disease in mouse models of two neurodegenerative disorders.
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