Flood of Exomes Brings Genetic Variation into Focus
Sequencing the protein-coding DNA regions of more than 60,000 people sheds light on disease-causing mutations.
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Tau PET Studies Agree—Tangles Follow Amyloid, Precede Atrophy
Researchers at AAIC presented congruent data on the place tau tangles take in AD progression, and their close correlation with cognitive decline.
Using Clinical Dx Only, Study Calls Stroke Clear Risk Factor for LOAD
While the relationship between Alzheimer’s and cardiovascular problems such as hypertension and diabetes remains complicated, a history of stroke is said to double the risk of late-onset AD.
Homing in on Early Alzheimer’s Biomarkers: Does Connectivity Hold the Key?
Researchers at AAIC proposed several different measures of brain connectivity that may predict progression to AD.
Late-Life Brain Workouts May Hold Off Dementia, Meta-Analysis Concludes
Even as a slew of confounding variables blur results, studies still converge on the benefit of a cognitively stimulating life in old age.
Book Surveys Past, Present, and Future of Alzheimer’s Therapeutics
Edited by Michael Wolfe and authored by leaders in the AD field, a new book challenges investigators to make real progress.
Amyloid and Neurodegeneration Have Different Underlying Genetics
Different genetic factors underlie amyloid accumulation and atrophy, researchers at AAIC reported.
AAIC Roundup—All the News From Toronto
Read our full coverage of this year’s AAIC conference.
Young Blood a Boon for APP Mice
Parabiosis passes its first test in mouse models of Alzheimer’s, normalizing gene expression and improving memory—though with no reduction in amyloid plaques.
γ-Secretase Gives Up Secrets About Its Cleavage
Researchers explain why the protease cuts at every third amino acid, shedding light on how some familial APP mutations are pathogenic.
Frontotemporal Dementia: The Hard Work of Pushing Toward Trials
With a laser focus on biomarkers and disease mechanisms, researchers at the 10th ICFTD meeting prepared the ground for therapeutic studies.
International Conference on Frontotemporal Dementias 2016
Frontotemporal Dementia: The Hard Work of Pushing Toward Trials First Round of FTD Therapeutics Fell Short, But Many More Are Up and Running Fluid NfL Shines, Tau PET Dims, in the Hunt for FTD Biomarkers Tests of Social Cognition Hold Potential as FTD Out
First Round of FTD Therapeutics Fell Short, But Many More Are Up and Running
Researchers reported negative findings from three trials at ICFTD 2016.
Fluid NfL Shines, Tau PET Dims, in the Hunt for FTD Biomarkers
Researchers at an international frontotemporal dementia congress reported progress in finding markers that track disease, but no luck thus far with diagnostic markers.
Tests of Social Cognition Hold Potential as FTD Outcome Measures
Several such tests generated enthusiasm at the international frontotemporal dementia congress.
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