Does C9ORF72 Repeat RNA Promote Protein Phase Transitions?
The ALS-linked RNA may convert free-floating proteins to liquid phase droplets.
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10th Brain Research Conference: RNA Metabolism in Neurological Disease
C9ORF72 Mice Point to Gain of Toxic Function in ALS, FTD Does C9ORF72 Repeat RNA Promote Protein Phase Transitions? RNA Regulator Locked Out of Nucleus by C9ORF72 Repeats Listen Up, Gene Silencing Strikes a Chord at RNA Meeting Stressed Out: RNA-binding P
Microglia Control Synapse Number in Multiple Disease States
Research presented at SfN strengthens the case that microglia gorge on synapses in some neurodegenerative and neurodevelopmental disorders.
RNA Regulator Locked Out of Nucleus by C9ORF72 Repeats
The RNA-binding protein hnRNP A3 can help rid a cell of the repeat RNAs, but the RNAs interfere with its nuclear localization.
Neurofilament Light Chain: A Useful Marker for AD Progression?
The protein creeps up in the cerebrospinal fluid as the disease worsens.
Potential Parkinson’s Treatments Target α-Synuclein, Cell Replacement
Two drugs that boost α-synuclein clearance have passed Phase 1 safety benchmarks, and a stem cell strategy is poised to enter trials, reported scientists at SfN 2015.
Alzheimer’s GWAS Hits Point to Endosomes, Synapses
Scientists at SfN offer alternate views of Bin1 biology.
And the Oscar of Science Goes to …
John Hardy wins the Breakthrough Prize for his seminal research into the genetic underpinnings of Alzheimer’s disease.
Listen Up, Gene Silencing Strikes a Chord at RNA Meeting
Scientists say treatments to muzzle faulty genes are making some headway.
Chuck Feeney Award to Bolster Dementia Prevention in Developing Countries
A philanthropic organization has donated $177 million to train thought leaders from developing nations in dementia care and prevention.
Stressed Out: RNA-binding Protein Inhabits Granules in ALS, FTD
Meet RBM45. This RNA-binding protein and relatively new player in the ALS field associates with stress-induced structures in the cytoplasm and nucleus.
Unexpected Polypeptides Pop Up in Huntington’s Disease
In a process known as repeat-associated non-ATG translation, neurons and glia make alanine, serine, cysteine, and leucine chains from the huntingtin gene.
Gantenerumab, Aducanumab: Bobbing Up and Down While Navigating Currents of Trial Design
Both antibodies might be working, experts say, but the latest data released at the CTAD conference remain tantalizingly unclear. Trialists urgently need progression predictors and better outcome measures.
Clinical Trials on Alzheimer’s Disease 2015
Gantenerumab, Aducanumab: Bobbing Up and Down While Navigating Currents of Trial Design Outcomes, Outcomes: Cognition is Crux of New Alzheimer’s Trials Truly New to Déjà Vu: Investigational Therapy News at CTAD Truly New to Déjà Vu: For Five Hopefuls, Lig
Outcomes, Outcomes: Cognition is Crux of New Alzheimer’s Trials
The CTAD conference featured discussion among many scientists of how to measure a drug’s effect in pre-dementia patients who are so mildly impaired that established tools have trouble picking up improvement. Better cognitive tools are needed.
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