Does Brain Development in Childhood Set the Stage for Dementia?
Research uncovers subtle links between early development problems and some forms of dementia.
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APP Secretases Play Tug of War with Growth Cones: Could Inhibitors Dictate the Winner?
Though BACE1 and γ-secretase appear to orchestrate axonal pathfinding, researchers doubt inhibitors or modulators of these proteases would cause side effects in people treated for AD.
Biomarkers Differentiate Parkinsonian Diseases and Forecast Decline
Can proteins in the cerebrospinal fluid help tell movement disorders apart and predict who will develop dementia?
At AAIC, Researchers Debate Neurogranin's Measure as a Marker
The synaptic protein abounds in the cerebrospinal fluid of AD patients and in those in the prodromal phase of the disease.
How Do You Communicate Alzheimer’s Risk in the Age of Prevention?
Prevention trials are testing new protocols for telling potential participants about their heightened risk for dementia, and exploring the psychological effect of such disclosures.
Testing a New Model for Disclosure of ApoE4 Status
The largest trial yet of ApoE4 carriers is pioneering new protocols with increasing use of technology to reach thousands of potential participants and disclose risk information.
Amyloid Scans in the Clinic: Seeing Is Believing?
Scanning for amyloid plaques in the brain may help clinicians diagnose and manage patients with a questionable diagnosis of Alzheimer’s.
World Alzheimer Report 2015: Revised Estimates Hint at Larger Epidemic
A new report paints a stark picture of the coming wave of dementia cases and their staggering cost if prevention or treatment fails to stem the tide.
Estrogen Therapy Could Hold Back Alzheimer’s, Shrink the Brain?
At AAIC, researchers reported that estrogen may decrease dementia risk if given to healthy women during early menopause.
Suspected Non-Alzheimer Pathophysiology: It’s Not Exactly a Snap
Scientists struggle to understand neurodegeneration in the SNAP syndrome.
When There's No Amyloid, It’s Not Alzheimer’s
Postmortem pathology confirms that some people who were diagnosed with AD during life had no appreciable amyloid in the brain, leaving researchers to puzzle over what caused their cognitive decline.
ALS-Linked Kinase Promotes Mitochondrial Destruction
TBK1 helps autophagy adaptors clutch damaged organelles.
Paper Alert: Longitudinal Data Support CSF Neurogranin as an Early Synaptic Marker of Alzheimer’s Disease
Neurogranin could be a promising early CSF biomarker of Alzheimer’s disease.
Rare but Severe Side Effects Sideline Some Phase 3 Encenicline Trials
Gastrointestinal adverse events prompted the FDA to press the pause button on the α7 nicotinic acetylcholine receptor agonist.
With ScaleS, You Can See Through the Brain to Behold Synapses
The latest optical-clearing technique exposes three-dimensional interactions between plaques, microglia, and blood vessels. It even zooms in on synapses.
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