Blood May Foretell Parkinson’s Up to Seven Years Prior
A panel of eight plasma proteins identified people who were on the path to Parkinson’s. Could this help select participants for prevention trials?
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PET Tracers For Non-Alzheimer’s Tauopathies Enter Clinical Testing
New candidate OXD-2314 binds 3R and 4R forms of tau and has begun Phase 1. The pan-tau tracer APN-1607 begins Phase 3 for progressive supranuclear palsy, a 4R tauopathy.
Could Neutrophils Be the Newest Players in Neurodegenerative Disease?
Preventing these peripheral phagocytes from creeping into the brain improves memory and ameliorates pathology in mouse models of Alzheimer’s.
Newly Identified Microglia Contain Lipid Droplets, Harm Brain
These cells accumulate in old mouse and human hippocampi, as well as in a mouse model of neurodegenerative disease.
Mounting Modifications Move Tau Toward Aggregation in Alzheimer’s Brain
Quantifying 95 post-translational modifications of tau extracted from AD and control brains, a proteomics study proposes a “processive” model of phosphorylation, ubiquitination, acetylation that drive aggregation and map to distinct stages of disease.
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Transcriptomes of more than 400 postmortem brains reveal microglia and astrocyte subtypes that collaborate to precipitate pathologic changes.
Crystal Structure of Aβ and Proposed Receptor Solved
A small molecule that protects neurons fends off a short region of Aβ from a specific pocket on the LilrB2 receptor.
Tau Filaments Found Tethered Inside Alzheimer's Brain Exosomes
Bound up in vesicles extracted from Alzheimer's brain, tau filaments adopt their characteristic back-to-back C-shape. A mystery molecule is involved in tying them down.
Large Neuropathology GWAS Finds Four New Dementia Genes
The analysis of nearly 8,000 brains turned up three genes linked to cerebrovascular disease, and one linked to tangles.
Sans Presenilin-2, Lysosomes Struggle. Synapses, Memory Circuits Erode
In mice, crippling PSEN2 worsened amyloid deposition, synaptic dysfunction, and deficit in working memory.
Following Footsteps of AD Vaccination: Passive Shots Against Prions Protect Mice
Passive antibody immunization against prion protein prevents the spread of clinical disease to the brain of mice, even though the antibody works primarily by reducing prion replication in peripheral tissues, including the spleen. This is the astonishing news in a report in today’s Nature...
Diagnosing the Early Stages of Alzheimer's
As a number of drug candidates to prevent, slow, or even halt Alzheimer's disease are being developed, a new urgency is driving efforts to develop tests that can diagnose the disease in its earliest stages...
Immunotherapy Protects against Synaptic Effects of Soluble Amyloid-β Oligomers
Originally, vaccination with amyloid-β (Aβ) peptides aimed to fight Alzheimer disease by...
Trisomy Trouble: Neurotrophin Signaling Defective in Down Syndrome
A pair of studies published in the July 6 Neuron show that in two different mouse models of Down syndrome, the cause of neuron death...
Madrid: BACE News Roundup, Part 3
This is part 3 of our 3-part series.
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