Scientists Seek, Find, and Exploit AD Risk Genes
Using creative ways of mining genetic data, researchers are coming up with new risk variants for Alzheimer’s.
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Mouse with Endogenous SOD1 Mutation: A New Model of Early ALS?
Chemical mutagenesis yields an SOD1 variant found in people with the disease. Neurons degenerate without overexpression of the enzyme.
New Target Has Legs: Tau PET, Mice, and Antibodies
Researchers at CTAD advanced tau research on several fronts, correlating tau PET with Braak stage and memory loss, and introducing a new tau model and therapeutic antibody.
Just for Her? Study of Women’s Biology Offers New Therapeutic Angle
New therapeutics such as plant-based estrogens and neurosteroids caught notice at CTAD as an approach to try to prevent cognitive decline in women who metabolic markers indicate may be at risk for Alzheimer's.
Live-Cell Studies Blame Arginine Peptides for C9ORF72’s Crimes
The ALS/FTD gene produces repeat dipeptides that enter the nucleolus and kill cells within days.
New Ideas for Alzheimer’s Treatment: What’s on Offer in 2015?
Speakers at CTAD presented new treatment approaches, including a combination of two repurposed drugs that have no activity by themselves.
Neurons Cave When Astrocytes Heap on the Complements
When provoked by Aβ, astrocytes unleash a torrent of inflammatory signals. Under it, neuronal dendrites wither and lingering synapses turn hyperactive.
Do Astrocyte Receptors Go Over the Top in Alzheimer’s?
In mouse models of AD, one astrocyte purinergic receptor makes glia hyperactive, while another may suppress memory. Both are upregulated in the AD brain, researchers report.
Nanobubbles: Potent Potion, or Just Effervescence?
Tiny spheres full of oxygen soothe neuroinflammation and fight neurodegeneration, researchers reported at SfN. The concept may seem strange, but AD trials are on the horizon.
Antibody Probe Seeks Aβ Oligomers in MRI
Scientists claim that MRI detects an Aβ oligomer-specific probe delivered to the mouse brain through the nose.
Guanine-Based RNA Tetrads Turn on Stress Granules, Rescue Neurons
Researchers mimic neuroprotective RNAs with stable DNAs that can do the same job.
Amino Acid Mimicry Leads Researchers to New Resveratrol Target
Posing as the amino acid tyrosine, the anti-aging compound resveratrol turns on a new target, PARP1.
A Year in Research—Top 10 Trends of 2014
Alzforum looks back on last year's research newsmakers.
Protein Marker Distinguishes Prion Disease from Rapid Alzheimer’s
Measuring total prion protein in cerebrospinal fluid could help clinicians differentiate between prion disease and rapidly progressing forms of dementia.
A Kinder, Gentler Implant
Like a second skin, a new kind of neural implant is as compliant as the protective dura membrane that envelops the central nervous system.
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