Lipoprotein Receptor Deficiency and Aβ—Spiraling Toward Alzheimer's?
Starved for a protein that regulates lipids, neurons suffer and Aβ production soars, according to a new study.
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Neuron-Protecting P7C3 Compounds Take Steps Toward the Clinic
Researchers have partnered with Google-funded Calico Life Sciences to develop a molecule that protects neurons in a variety of conditions.
Does TDP-43 Oligomerize and Coax Aβ to Do the Same?
Protein oligomers may be to blame in TDP-43 proteinopathies, as in other neurodegenerative conditions.
Memory Concerns Presage Cognitive Decline and Aβ Pathology
Older people who complain of memory problems are more likely to become measurably impaired and to have Alzheimer’s pathology in the brain, especially if they smoke or carry an ApoE4 allele.
At Birthday Symposium, Massachusetts ADRC Looks to Future With New Data
MGH meeting traces arc of scientific discoveries from 1980s to today’s cutting edge.
Massachusetts Alzheimer's Disease Research Center's 30th Anniversary Symposium
At Birthday Symposium, Massachusetts ADRC Looks to Future With New Data As the first five of the nation’s 27 Alzheimer’s Disease Research Centers system marked their 30th birthday, one of them celebrated with a scientific conference at Massachusetts Gener
Does Progranulin in Microglia Protect Against Alzheimer’s?
In mouse models, removing this growth factor only from immune cells worsened pathology and memory.
Cellular Biosensor Detects Tau Seeds Long Before They Sprout Pathology
A new assay detects tau and α-synuclein seeds in human brain samples. Could it become a diagnostic?
Do Neurotrophin and ApoE Together Exacerbate Alzheimer's?
A study claims that two genetic variants combined may hasten cognitive decline in people who have Aβ deposits in the brain.
Lilly Teams Up With AstraZeneca for BACE Inhibitor Phase 2/3 Trial
The pharma giant puts up funding to help develop AstraZeneca’s inhibitor, the second such compound to enter Phase 2 testing.
ALS, Parkinson’s Proteins Co-Mingle in Mitochondria Destruction Pathway
ALS-linked optineurin works closely with Parkinson’s-associated Pink1 and parkin in a pathway that recycles mitochondria.
Phase 2 Trial Hints Idalopirdine May Work as Adjunct Therapy in Alzheimer’s
Results suggest the drug boosts cognition when given alongside the acetylcholinesterase inhibitor.
Forget Mice—Are Human Cells Better for Drug Testing?
Therapeutics that target γ-secretase produced different results in human neurons and mouse models of Alzheimer’s disease.
Nature/Aventis Horizon Symposium: Understanding the RNAissance
News Pointer: RNAi Horizon Symposium Highlights Nature/Aventis Horizon Symposium: Understanding the RNAissance
American Aging Association: 2005 Annual Meeting
Oakland: Food for Thought at American Aging Association Annual Meeting Oakland: Caloric Restriction Set for Primate Time? Oakland: Are Mitochondria the Key to Longevity? American Aging Association: 2005 Annual Meeting
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