Nothing to Sneeze At: Viruses Raise Risk of Neurodegenerative Disease
Twelve severe viral illnesses boosted risk up to 15 years after infection.
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Better Cell Model? Transdifferentiated Neurons Capture AD-Like Changes
New studies report that transdifferentiated neurons from AD patients retain signatures of aging. They also model lysosomal dysfunction, tau phosphorylation, and cell death.
Potential CSF Biomarkers Detect Roused Microglia in AD, FTD
The panel of six marker candidates includes proteins involved in lipid processing and metabolism in microglia.
Atlas of Mouse Brain Aging Finds Biggest Changes in White Matter
The comprehensive survey of brain-wide gene expression over the lifespan flagged glial cells in white matter as potential drivers of aging.
Could Inhibiting a Liver Enzyme Ameliorate Alzheimer’s Pathology in the Brain?
In mice, curbing a hepatic hydrolase boosted protective epoxy fatty acids in the brain, which stimulated microglia to clear amyloid.
Alzheimer’s, Primary Age-Related Tauopathy Take Separate Paths
Compared to AD, tau tangles in PART accumulated slowly, and only in the medial temporal lobe. Cognition slipped subtly, and no amyloid amassed over three years.
Could Blood Transfusions Transmit Vascular Amyloid?
A retrospective study found an increased risk of brain bleeds in people who received blood from someone else with such bleeds, hinting at a soluble agent. Aβ?
Endolysosomal TMEM106b Regulates Myelin Lipid Metabolism
The transmembrane protein tempers an enzyme that destroys lipids comprising myelin. Sans TMEM106b, lipid levels drop, and the myelin may be compromised.
Acetylation Accelerates Aggregation of 3R, but Not 4R, Tau
Acetylation of lysine residues unique to 4R tau hinders protofibril folding. The findings might explain selective 3R tau deposition in Pick’s disease.
After a Decade, Amyloid PET Scans Receive Broad Insurance Coverage
CMS has lifted restrictions that allowed beneficiaries one scan per lifetime as part of a clinical study. Approval of immunotherapies was a key factor.
AD Genetic Risk Tied to Changes in Microglial Gene Expression
Functional variants of AD GWAS hits found in enhancers of myeloid genes.
Can a Fatty Acid Explain Sex Differences in Parkinson’s?
Adding palmitate makes an estrogen receptor linger at the synapse, curbing α-synuclein aggregation, motor deficits, and faulty memory. In mice.
Do APOE4’s Lipid Shenanigans Trigger Tauopathy?
Faulty lipid metabolism is being blamed for supercharging tau phosphorylation. Restoring lipid efflux protects the mouse brain.
Transient Filament Yields AD and CTE Tau Fibrils
Cryo-EM reveals a common conformational progenitor for tau filaments found in Alzheimer’s disease and chronic traumatic encephalopathy.
Are T Cells to Blame for Cognitive Impairment Caused by Hypertension?
In the dura, these lymphocytes release interleukin 17, activating perivascular macrophages. They curb cerebral blood flow, and mice become forgetful.
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