Blood Metabolome Predicts 23 Diseases, Including Dementia
Analysis of 168 metabolites in one blood sample foretold 10-year risk of developing common disorders.
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Differential Diagnosis: Can Synaptic Proteins Get It Done?
VAMP2 helps distinguish pure dementia with Lewy bodies from DLB with Alzheimer’s. A synaptic protein panel distinguished FTLD-TDP-43 from FTLD-tau.
In Hydrocephalus, Slow Drainage May Cause Dementia
Slow clearance of an MRI tracer offers evidence of inefficient glymph transport in the brain.
Sharp at 100+? Thank You, Genes. Thank You, Immune System.
Staying lucid as a centenarian may depend on the immune system you inherit.
Kuopio Alzheimer Symposium (9th) and Nordic Memory Clinic Conference (3rd)
Sharp at 100+? Thank You, Genes. Thank You, Immune System. In Hydrocephalus, Does Slow Drainage Cause Dementia? Differential Diagnosis: Can Synaptic Proteins Get It Done? Kuopio Alzheimer Symposium (9th) and Nordic Memory Clinic Conference (3rd)
FDA Approves ALS Drug on Phase 2 Data
The agency, under pressure from advocacy groups, considers uncertainty about efficacy to be acceptable.
Up, and Down—Haptoglobin Moves APOE4 Risk in Mysterious Ways
The blood protein tempers APOE4 risk in E2 carriers yet accentuates it in E4 homozygote people.
LRRK2 Variants Keep α-Synuclein from Forming Tetramers
The Parkinson’s-related proteins promoted pathological hyperphosphorylation of α-synuclein.
In Mini-Pigs Missing SORL1, Endosomes Swell and Aβ Peptides Rise in CSF
The animals had no plaques or tangles, although they are still young.
Finally: Big Win on All Outcomes for Lecanemab in Phase 3 Topline Results
Drug sponsors Eisai and Biogen said they will apply for approval in Europe, the U.S., and Japan; more detailed data will be presented at CTAD.
Windfall Week for Trial Data: Papers on Crenezumab, Neflamapimod, Tofersen
Three drugs, targeting three different pathogenic mechanisms in Alzheimer's, dementia with Lewy bodies, and ALS, had trial data formally published this week.
Can 10,000 Steps a Day Keep Dementia at Bay?
Adults who hit this number were half as likely as their sedentary peers to develop dementia over seven years. Power walking for 30 minutes daily cut risk by 60 percent.
As Health Problems Pile Up, Dementia Climbs on Top of the Heap
According to findings from more than 200,000 people 60 and older, having multiple chronic diseases nearly doubles the risk of dementia within the next 12 years.
Pseudotime Simulates Disease Progression from Case-Control RNA-Seq
Aligning single-cell gene expression in “pseudotime” models longitudinal change. It explores how healthy cells become sick during Alzheimer's.
Meta-Analysis of RNA-Seq Data is Robust, Finds Key Changes in AD
By pooling single-nucleus RNA-sequencing datasets, scientists found consistent changes across Alzheimer’s cohorts. Examples: hypermetabolic transcription, and a new neuron population that dies early on.
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