Tau Aggregates Awaken Genetic Relics in the Brain
By prying open chromatin, neurofibrillary tau may expose dormant transposable elements for transcription.
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Invading Microglia Unleash Neurodegeneration in 3D AD Culture
Microfluidic tri-culture of neurons, astrocytes, and microglia models how glia impose deadly neuroinflammation on top of amyloid and tau pathology.
Senate Approves $2.34 Billion Budget for Alzheimer’s Research
The 2019 budget ups this year’s spending by $425 million.
Conformers Confirmed: Structure of Pick’s Tau Distinct from AD Tau
A molecular-level view of tau filaments from a person with Pick’s disease reveals that the protein folds up differently than it does in Alzheimer’s disease.
Lifestyle Coaching Slows Cognitive Decline in African-Americans with MCI
A behavioral intervention slowed memory slippage and functional decline over two years.
Exercise Linked to Less Pathology, Better Function in Familial AD
In DIAN, participants who are more physically active may also have slower disease progression.
Across Time and Space: Machine Learning Reveals Paths to Dementia
Analysis of MRI brain volume data identifies multiple AD and FTD/ALS disease subtypes with distinct patterns of degeneration over time.
Islands of Mutated Neurons Dot the Brain. Are They Bad for Us?
Clusters of neurons harboring somatic mutations in 56 genes linked to neurodegenerative diseases may be commonplace in the human brain.
Does Oleic Acid Hold the Key to α-Synuclein Toxicity?
In several model systems, α-synuclein boosts oleic acid production and the fatty acid worsens α-synuclein pathology.
Secreted APP Binds GABA-B Receptors, Blocks Neurotransmitter Release
In presynapses, binding sequesters synaptic vesicles.
Absent Aβ, Blood-Brain Barrier Breakdown Predicts Cognitive Impairment
A leaky blood-brain barrier in the hippocampus correlated with cognitive impairment, independently of other vascular risk factors or Alzheimer’s pathology.
Microtubule Regulator Connects TDP-43 to Axonal Dysfunction
Two independent studies find that loss of nuclear TDP-43 leads to mis-splicing of stathmin 2, an essential protein for axon growth and repair.
Rogue Gene Networks Track with Neurodegeneration Across Diseases
Aberrant gene-expression patterns found to be common to human neurodegenerative disease and animal models. MicroRNA and epigenetic modification may be to blame.
Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques
Boosting sTREM2 in the brain rallied microglia to clear Aβ plaques, restored synaptic plasticity, and even rescued memory deficits in mice.
ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s
Scientists know that the retina changes in people with preclinical AD; alas, there is neither consensus nor convergence in the field of retinal imaging. An upcoming initiative aims to determine which measures are most robust.
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